Complement component 2 deficiency
Última actualización 18 Aug 2020
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Complement component 2 deficiency is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Immunodeficiencies are conditions in which the immune system is not able to protect the body effectively from foreign invaders such as bacteria and viruses. People with complement component 2 deficiency have a significantly increased risk of recurrent bacterial infections, specifically of the lungs (pneumonia), the membrane covering the brain and spinal cord (meningitis), and the blood (sepsis), which may be life-threatening. These infections most commonly occur in infancy and childhood and become less frequent in adolescence and adulthood.
Descripción
Complement component 2 deficiency is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. Immunodeficiencies are conditions in which the immune system is not able to protect the body effectively from foreign invaders such as bacteria and viruses. People with complement component 2 deficiency have a significantly increased risk of recurrent bacterial infections, specifically of the lungs (pneumonia), the membrane covering the brain and spinal cord (meningitis), and the blood (sepsis), which may be life-threatening. These infections most commonly occur in infancy and childhood and become less frequent in adolescence and adulthood.
Complement component 2 deficiency is also associated with an increased risk of developing autoimmune disorders such as systemic lupus erythematosus (SLE) or vasculitis. Autoimmune disorders occur when the immune system malfunctions and attacks the body's tissues and organs. Between 10 and 20 percent of individuals with complement component 2 deficiency develop SLE. Females with complement component 2 deficiency are more likely to have SLE than affected males, but this is also true of SLE in the general population.
The severity of complement component 2 deficiency varies widely. While some affected individuals experience recurrent infections and other immune system difficulties, others do not have any health problems related to the disorder.
Patrones de herencia
The source lists the following possible inheritance patterns: Autosomal recessive. More than one pattern can apply in different cases.
Related genes
Otros nombres
C2 deficiency
C2D
Complement 2 deficiency
Related patient information and medicines
Patient information leaflet
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Taking high doses... Deficiencia de G6PD Very high doses of vitamin C can cause oxidative stress and lead to the breakdown of red blood cells (haemolysis) in individuals with G6PD deficiency. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Disclaimer.
Patient information leaflet
Deficiencia de vitamina D
Vitamin D deficiency happens when your body does not have enough vitamin D. This is a nutrient that helps keep bones, teeth, and muscles healthy. Vitamin D deficiency is common, especially in people who get little sunlight or have low vitamin D intake from their diet. What is vitamin D deficiency. This can as... Treatment of vitamin D deficiency.
Patient information leaflet
¿Puedo tomar Magnesio y Vitamina C juntos?
There is no harmful interaction between magnesium and vitamin C. G6PD deficiency Very high doses of vitamin C can cause oxidative stress and lead to the breakdown of red blood cells (haemolysis) in individuals with G6PD deficiency. Haemochromatosis High doses of vitamin C can significantly increase the amount of iron your body absorbs from food..
Patient information leaflet
Deficiencia de vitamina C
Vitamina C cannot be made by the human body and so is an essential component of the diet. It is needed for the health and repair of various tissues in the body, including skin, bone, teeth and cartilage. Persistent lack of dietary vitamin C in can lead to a condition called scurvy. Symptoms of scurvy include easy bruising, easy bleeding and joint.
Patient information leaflet
¿Puedo tomar Hidroxocobalamina y Stexerol D3 juntos?
It is safe to take these two medications together. Why this happens Hydroxocobalamin es a form of Vitamin B12, and Stexerol-D3 es a brand of Vitamin D3 (cholecalciferol). These vitamins are processed by different pathways in the body and do not interfere with each other's absorption, metabolism, or effectiveness. Our Medicines Interaction Checker.
Patient information leaflet
¿Puedo tomar ácido fólico y vitamina D juntos?
Hay no known harmful interactions between folic acid (Vitamin B9) and Vitamin D. In fact, these two vitamins are frequently taken together in multivitamins and prenatal supplements. Precauciones importantes Deficiencia de vitamina B12 (Pernicious Anaemia) Ácido fólico puede máscara el symptoms of vitamin B12 deficiency. ...ve B12 deficiency, taking folic.
Lecturas adicionales y referencias
- Complement component 2 deficiency; MedlinePlus, National Library of Medicine.
- Jonsson G, Sjoholm AG, Truedsson L, Bengtsson AA, Braconier JH, Sturfelt G. Rheumatological manifestations, organ damage and autoimmunity in hereditary C2 deficiency. Rheumatology (Oxford). 2007 Jul;46(7):1133-9. doi: 10.1093/rheumatology/kem023. Epub 2007 May 3.
- Jonsson G, Truedsson L, Sturfelt G, Oxelius VA, Braconier JH, Sjoholm AG. Hereditary C2 deficiency in Sweden: frequent occurrence of invasive infection, atherosclerosis, and rheumatic disease. Medicine (Baltimore). 2005 Jan;84(1):23-34. doi: 10.1097/01.md.0000152371.22747.1e.
- Sjoholm AG, Jonsson G, Braconier JH, Sturfelt G, Truedsson L. Complement deficiency and disease: an update. Mol Immunol. 2006 Jan;43(1-2):78-85. doi: 10.1016/j.molimm.2005.06.025.
- Skattum L, van Deuren M, van der Poll T, Truedsson L. Complement deficiency states and associated infections. Mol Immunol. 2011 Aug;48(14):1643-55. doi: 10.1016/j.molimm.2011.05.001. Epub 2011 May 31.
- Truedsson L, Bengtsson AA, Sturfelt G. Complement deficiencies and systemic lupus erythematosus. Autoimmunity. 2007 Dec;40(8):560-6. doi: 10.1080/08916930701510673.
- Wen L, Atkinson JP, Giclas PC. Clinical and laboratory evaluation of complement deficiency. J Allergy Clin Immunol. 2004 Apr;113(4):585-93; quiz 594. doi: 10.1016/j.jaci.2004.02.003.
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