Can I take Prozac and Wellbutrin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking Prozac (fluoxetine) and Wellbutrin (bupropion) together can significantly increase the levels of Prozac in your blood. This can lead to an increased risk of side effects such as anxiety, sleep problems, tremors, or jitteriness. More seriously, both medications can lower the 'seizure threshold', meaning there is a higher risk of having a seizure when they are combined. There is also a small risk of 'serotonin syndrome', a rare but serious condition caused by too much serotonin in the brain.
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Why this happens
Wellbutrin (bupropion) blocks a specific liver enzyme (CYP2D6) that the body uses to break down Prozac (fluoxetine). Because the Prozac isn't being cleared out as quickly, it builds up to higher levels. Additionally, both drugs affect brain chemicals in a way that can make the brain more prone to seizures.
What you should do
You must speak to your doctor before taking these together. If your doctor decides this combination is necessary, they may prescribe a lower dose of one or both medications. Seek immediate medical help if you experience a seizure, extreme confusion, severe muscle stiffness, or a very high fever.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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