Can I take Omeprazole and Pyridostigmine together?
Drug interaction guide
Originally published 25 Jan 2026
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Omeprazole may reduce the effectiveness of pyridostigmine, potentially causing your muscle weakness symptoms to return or worsen.
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Why this happens
Pyridostigmine works best in an acidic stomach environment. Omeprazole reduces stomach acid, which can prevent pyridostigmine from being absorbed properly into your bloodstream.
What you should do
Speak to your doctor before taking these together. They may suggest timing the doses further apart or monitoring your symptoms closely. If you notice increased muscle weakness or difficulty swallowing, contact your healthcare provider immediately.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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