Can I take Naproxen and Omeprazole together?
Guía de interacción de medicamentos
Publicado originalmente 25 Ene 2026
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Omeprazole is often prescribed alongside naproxen to protect your stomach. While omeprazole can slightly change how quickly naproxen is absorbed into your bloodstream, this is not usually a problem and does not make the painkiller less effective. In fact, taking them together is a common way to prevent stomach ulcers caused by anti-inflammatory drugs.
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Por qué sucede esto
Omeprazole reduces stomach acid, which can slightly slow down the rate at which naproxen dissolves and enters the blood. However, it does not change the total amount of naproxen that your body receives. This is a beneficial interaction because omeprazole protects the stomach lining from the irritating effects of naproxen.
Lo que deberías hacer
Volver al contenidoIt is safe and often recommended to take these two medicines together. You should follow your doctor's instructions on when to take each one. Usually, omeprazole is taken in the morning on an empty stomach, while naproxen should be taken with or after food to further protect your stomach.
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Precauciones importantes
Volver al contenidoAsma
Do not take naproxen if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack or severe breathing difficulties.
Úlceras estomacales o sangrado
Naproxen significantly increases the risk of stomach ulcers and internal bleeding. Omeprazole is often prescribed alongside it to reduce this risk, but you must seek immediate medical help if you pass black, tarry stools or vomit blood.
Embarazo (tercer trimestre)
Do not take naproxen if you are more than 20 weeks pregnant. It can cause serious kidney or heart problems in the unborn baby and may lead to complications during delivery.
Diarrea severa
Contacta a tu médico de inmediato si desarrollas diarrea acuosa severa o persistente, ya que el omeprazol puede aumentar el riesgo de una infección intestinal grave llamada Clostridium difficile.
Advertencias sobre alimentos y bebidas
Volver al contenidoAlcohol
Drinking alcohol while taking naproxen can increase the risk of irritation to your stomach lining and may increase the risk of stomach ulcers or bleeding. It is best to limit or avoid alcohol while taking this medicine.
Es mejor evitar o limitar estrictamente el consumo de alcohol mientras toma omeprazol. El alcohol puede aumentar la cantidad de ácido que produce su estómago, lo que puede empeorar sus síntomas o hacer que el medicamento sea menos efectivo. Además, tanto el alcohol como el omeprazol pueden irritar el revestimiento del estómago.
Alimentos (General)
You should take naproxen with or after food. This helps to protect your stomach lining and reduces the chance of side effects like indigestion or stomach pain.
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Uso de otros medicamentos
Volver al contenidoTaking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
25 Ene 2026 | Publicado originalmente

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