Can I take Lercanidipine and Promethazine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can cause your blood pressure to drop lower than intended. This might make you feel dizzy, lightheaded, or faint, especially when standing up quickly. Additionally, both drugs can cause drowsiness, which may be more intense when they are used at the same time.
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Why this happens
Lercanidipine works by relaxing your blood vessels to lower blood pressure. Promethazine, while primarily an antihistamine, can also cause blood vessels to widen slightly and has a sedating effect on the brain. When combined, these effects add together, increasing the risk of low blood pressure and sleepiness.
What you should do
You should use caution when taking these medicines together. Monitor your blood pressure regularly and be careful when getting out of bed or standing up. If you feel very dizzy or sleepy, avoid driving or operating machinery. If you experience fainting or severe dizziness, contact your doctor to see if your doses need adjusting.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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