¿Puedo tomar ácido fólico y metotrexato juntos?

Por qué sucede esto

Methotrexate works by blocking the body's use of folate (a B vitamin) to stop certain cells from growing too quickly. Folic acid is a man-made version of folate. While it helps protect healthy cells from methotrexate's side effects, too much of it can "compete" with the medicine, potentially stopping it from working properly against the disease.

Lo que deberías hacer

You must follow your doctor's specific schedule for these medicines. Usually, you will be told NOT to take folic acid on the same day as your methotrexate dose. Do not start taking over-the-counter folic acid supplements or multivitamins containing folic acid without checking with your specialist first.

Precauciones importantes

Embarazo y anticoncepción

Methotrexate can cause severe birth defects or miscarriage. You must use effective contraception during treatment and for at least 6 months after stopping (applies to both men and women).

Dosing schedule and folic acid use

Methotrexate is usually taken only ONCE A WEEK on the same day. Taking it daily can be fatal. Folic acid must be taken on a different day to methotrexate to help reduce serious side effects.

Infection and blood disorders

Methotrexate can lower your white blood cell count, making you more likely to get serious infections. Seek urgent medical help if you develop a fever, sore throat, or unexplained bruising/bleeding.

Deficiencia de vitamina B12 (Anemia Perniciosa)

El ácido fólico puede enmascarar los síntomas de la deficiencia de vitamina B12. Si tienes deficiencia de B12, tomar ácido fólico solo puede permitir que el daño grave a los nervios progrese, incluso si tu conteo sanguíneo parece normal. Tu médico debe asegurarse de que tus niveles de B12 sean revisados antes o durante el tratamiento.

Advertencias sobre alimentos y bebidas

Alcohol

You should strictly limit or avoid alcohol while taking methotrexate. Both alcohol and methotrexate can cause liver damage, and taking them together significantly increases the risk of serious liver problems. Your doctor will advise you on whether a very small amount is safe for you based on your blood tests.

Es mejor evitar o limitar estrictamente el alcohol mientras se toma ácido fólico. El alcohol interfiere con la forma en que tu cuerpo absorbe y utiliza el ácido fólico, lo que puede hacer que el tratamiento sea menos efectivo. El consumo crónico de alcohol es una causa común de deficiencia de folato.

Caffeine (Coffee, Tea, Cola)

Large amounts of caffeine may reduce how well methotrexate works for some conditions like rheumatoid arthritis. If you notice your symptoms worsening, try to limit your intake of coffee, strong tea, and caffeinated soft drinks.

Productos lácteos

Avoid consuming large amounts of milk or dairy products at the exact same time you take your methotrexate dose. Dairy contains an enzyme that may slightly interfere with how the medicine is absorbed. It is fine to eat dairy at other times of the day.

Folic acid supplements (outside of prescribed dose)

While you have been prescribed folic acid to reduce side effects, do not take extra 'over-the-counter' multivitamins or fortified foods containing high levels of folic acid unless your doctor agrees. Taking too much folic acid on the same day as methotrexate can make the treatment less effective.

Uso de otros medicamentos

¿Tomas múltiples medicamentos? Nuestro Verificador de Interacciones de Medicamentos te ayuda a verificar si tus recetas, medicamentos de venta libre y suplementos son seguros para tomar juntos. Simplemente busca tus medicamentos para ver posibles interacciones y qué hacer al respecto.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.