Can I take Amlodipine and Nustendi together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amlodipine and Nustendi (ezetimibe) together can increase the amount of one of the ingredients in Nustendi (bempedoic acid) in your bloodstream. This may increase the risk of side effects from Nustendi, such as high levels of uric acid in the blood (which can cause gout) or, in rare cases, tendon problems.
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Why this happens
Amlodipine can slightly interfere with the way the body processes bempedoic acid (a component of Nustendi), leading to higher levels of the medication staying in your system for longer.
What you should do
Back to contentsIt is generally safe to take these together, but your doctor should be aware. They may want to monitor your uric acid levels more closely or check for any signs of muscle or tendon pain. If you experience any unusual joint pain or swelling, contact your doctor.
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Important precautions
Back to contentsEmbarazo
You must not take Nustendi if you are pregnant or breastfeeding. If you are a woman who could become pregnant, you must use effective contraception while taking it. Stop taking it immediately and tell your doctor if you become pregnant.
Gota
Nustendi can increase the levels of uric acid in your blood, which may cause gout. Tell your doctor if you have ever had gout or if you develop painful, swollen joints.
Food and drink warnings
Back to contentsGrapefruit and grapefruit juice
Grapefruit can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swollen ankles. Avoid consuming large amounts of grapefruit or its juice while taking this medicine.
Alcohol
While there is no direct interaction, alcohol can lower your blood pressure. Combining it with amlodipine may make you feel dizzy or lightheaded. Additionally, both Nustendi and heavy alcohol use can affect your liver; it is best to keep your intake within the recommended limits (14 units per week).
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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