Can I take Fexofenadine and Trazodone together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking fexofenadine and trazodone together may increase the risk of feeling very sleepy, dizzy, or having difficulty concentrating. While fexofenadine is a 'non-drowsy' antihistamine, it can still cause mild sedation in some people, which may add to the strong sedative effects of trazodone.
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Why this happens
Both medications can affect the central nervous system. Trazodone is a sedative antidepressant, and fexofenadine, although designed not to enter the brain easily, can occasionally cause mild drowsiness. When used together, these effects can combine (additive effect).
What you should do
It is generally safe to take these together, but you should be aware of how they affect you. Avoid driving or operating heavy machinery until you know how this combination makes you feel. If you experience extreme sleepiness or feel very unsteady on your feet, speak to your doctor or pharmacist.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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