Can I take Fexofenadine and Tizanidine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking fexofenadine and tizanidine together may increase the risk of side effects like drowsiness, dizziness, and dry mouth. While fexofenadine is a 'non-drowsy' antihistamine, it can still cause mild sleepiness in some people, which may add to the strong sedative effect of tizanidine.
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Why this happens
This is a 'pharmacodynamic' interaction. Both drugs can affect the central nervous system and have 'anticholinergic' properties (causing dryness). When taken together, their individual side effects can add up, making you feel more tired or dizzy than usual.
What you should do
You can take these medicines together, but you should be cautious. Monitor how you feel, especially when you first start the combination. Avoid driving or operating machinery if you feel particularly sleepy or dizzy. If these side effects become bothersome, speak to your doctor or pharmacist.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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