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Can I take Amlodipine and Aspirin together?

Drug interaction guide

Taking amlodipine and aspirin together is generally considered safe, but there is a small chance that aspirin could slightly reduce how well amlodipine works to lower your blood pressure. Additionally, both medications can independently increase the risk of stomach irritation or bruising, though this is rarely a significant problem at standard doses.

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Why this happens

Aspirin belongs to a group of medicines called NSAIDs. These can sometimes cause the body to hold onto salt and water, and they can interfere with natural chemicals called prostaglandins that help keep blood vessels relaxed. This can slightly counteract the blood-pressure-lowering effect of amlodipine.

You can usually take these two medicines together. However, you should monitor your blood pressure regularly to ensure it stays within the target range set by your doctor. If you notice your blood pressure rising or if you experience unusual bruising or stomach pain, speak to your GP or pharmacist.

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Asma

Do not take aspirin if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe, life-threatening asthma attack.

Stomach ulcers or bleeding disorders

Avoid aspirin if you have an active stomach ulcer or a history of bleeding problems, as it significantly increases the risk of serious internal bleeding.

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your body and may cause your blood pressure to drop too low. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcohol

Drinking alcohol while taking aspirin can increase the risk of irritation and bleeding in your stomach. It is best to limit alcohol intake or avoid it if you have a sensitive stomach.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Historia del artículo

La información de esta página ha sido redactada y revisada por médicos cualificados.

  • 25 Enero 2026 | Publicado originalmente
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