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Can I take Diazepam and Morphine together?

Guía de interacción de medicamentos

Taking diazepam and morphine together can cause extreme sleepiness, very slow or shallow breathing, and difficulty staying awake. In severe cases, this combination can lead to a coma or be life-threatening.

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Por qué sucede esto

Both drugs are 'central nervous system depressants'. This means they both slow down brain activity and the signals that tell your body to breathe. When taken together, their effects add up, making the sedation and breathing problems much stronger than if either drug were taken alone.

You should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. If you must take both, use the lowest dose possible for the shortest time. Seek emergency medical help immediately if you experience extreme dizziness, fainting, very slow breathing, or if you cannot stay awake. Avoid alcohol and do not drive or operate machinery while taking this combination.

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Respiratory conditions (e.g. COPD, severe asthma) or sleep apnoea

Both medicines can significantly slow your breathing. Taking them together, or if you already have lung problems, can cause life-threatening breathing difficulties.

Long-term use (Dependence)

These medicines are highly addictive. Using them for more than a few weeks can lead to physical dependence and severe withdrawal symptoms if stopped suddenly.

Driving and operating machinery

It is often an offence to drive while taking diazepam as it can seriously impair your coordination and reaction times. Do not drive or operate machinery until you know how this medicine affects you, and always keep the medicine in its original packaging to show the police if stopped.

Embarazo

Avoid use in late pregnancy or during labour, as it can cause 'floppy infant syndrome' and life-threatening withdrawal symptoms in the newborn.

Alcohol

It is best to avoid or strictly limit alcohol while taking diazepam. Combining them can cause dangerous levels of drowsiness, breathing difficulties, and may lead to a coma. It also significantly increases the risk of accidents.

It is best to avoid or strictly limit alcohol while taking morphine. Combining alcohol with morphine significantly increases the risk of dangerous side effects, such as extreme sleepiness, breathing difficulties, and a potentially fatal overdose.

Jugo de toronja

Avoid drinking grapefruit juice or eating grapefruit while taking diazepam. Grapefruit contains compounds that stop your body from breaking down the medicine properly, which can lead to higher levels of the drug in your blood and increase the risk of side effects.

Cafeína (Café, té, bebidas energéticas)

Caffeine can reduce the calming effects of diazepam. Because caffeine is a stimulant and diazepam is a sedative, they work against each other, making the medicine less effective.

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Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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