Can I take Vitamin d and Wellbutrin together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known significant interactions between vitamin D and Wellbutrin (bupropion). It is generally considered safe to take these two together.
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Why this happens
Vitamin D and bupropion are processed by different pathways in the body. Vitamin D is a fat-soluble vitamin primarily processed by the liver and kidneys to its active form, while bupropion is metabolised mainly by the CYP2B6 enzyme system. They do not interfere with each other's absorption, breakdown, or effectiveness.
What you should do
You can continue taking both as prescribed. As with any supplement, it is best to take vitamin D with a meal containing some fat to help with absorption. If you experience any unusual symptoms, consult your doctor or pharmacist.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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