Can I take Pregabalin and Venlafaxine together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking pregabalin and venlafaxine together can increase the risk of side effects that affect your central nervous system. You may feel more drowsy, dizzy, or sleepy than usual. It can also lead to difficulty concentrating, confusion, and a higher risk of falls, especially in older adults. In rare cases, it may cause breathing difficulties.
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Why this happens
Both medications have 'depressant' effects on the central nervous system. While they work in different ways, their sedative effects add together (an additive effect), making the overall impact on your alertness and coordination much stronger than if you took either medicine alone.
What you should do
You should use caution when taking these two medicines together. Avoid driving or operating heavy machinery until you know how this combination affects you. It is best to avoid alcohol, as it will make the drowsiness much worse. If you experience extreme sleepiness, confusion, or shallow breathing, contact your doctor immediately.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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