Can I take Lercanidipine and Vitamin D3 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known interaction between lercanidipine and vitamin D3 (cholecalciferol). It is generally safe to take these two together.
Why this happens
Lercanidipine is a calcium channel blocker used for high blood pressure, and vitamin D3 helps the body absorb calcium for bone health. While they both involve calcium pathways, they work in different ways and do not interfere with each other's absorption or breakdown in the body.
What you should do
You can continue taking both as prescribed. It is always a good idea to inform your doctor or pharmacist of all supplements you are taking, but no special precautions are needed for this combination.
Important precautions
Severe liver or kidney disease
Lercanidipine is not recommended if you have severe liver or kidney problems. Ensure your doctor is aware of your condition before starting treatment.
Hypercalcaemia (high blood calcium levels)
Do not take vitamin D3 if you have high levels of calcium in your blood or urine, as this supplement will further increase these levels and may cause kidney damage.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol while taking lercanidipine. Alcohol can increase the blood-pressure-lowering effect of the medicine, which may make you feel dizzy, lightheaded, or faint.
Grapefruit and grapefruit juice
You must not eat grapefruit or drink grapefruit juice while taking lercanidipine. Grapefruit can significantly increase the amount of the medicine in your blood, making side effects like dizziness, headaches, and a fast heartbeat much more likely.
High-fat meals
Lercanidipine should be taken at least 15 minutes before a meal. Taking it with or immediately after a high-fat meal can significantly increase the amount of medicine absorbed by your body, which may lead to more side effects.
Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Maitake and Turkey tail together?
There are no known harmful interactions between maitake and turkey tail mushrooms. Both are medicinal fungi that are often taken together to support the immune system. However, because both can stimulate the immune system, there is a theoretical possibility of an additive effect.

Drug interactions checker
Can I take Mounjaro and Metformin together?
When taken together, Mounjaro and Metformin can increase the risk of your blood sugar levels dropping too low (hypoglycaemia). While both drugs work to lower blood sugar, they do so in different ways, which can sometimes lead to an additive effect. Additionally, Mounjaro slows down how quickly your stomach empties, which might slightly change how your body absorbs Metformin, though this is usually not a major concern.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
Join the conversation
Share your thoughts or experiences with others in our patient communities.

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Anastrozole and Omeprazole together?
- Can I take antihistamines with alcohol?
- Can I take Atenolol and Rybelsus (semaglutide) together?
- Can I take Atorvastatin and Clopidogrel together?
- Can I take Atorvastatin and Maitake together?
- Can I take Cannabis and Clozapine together?
- Can I take Cetirizine and Paracetamol together?
- Can I take Cordyceps and Lions mane together?
- Can I take Evening primrose oil and Ginger together?
- Can I take Furosemide and Strivit D3 together?
- Can I take Gabapentin and Omeprazole together?
- Can I take Glibenclamide and Empagliflozin together?
- Can I take Glucosamine and Magnesium together?
- Can I take Hydroxychloroquine and Sildenafil together?
- Can I take Levothyroxine and Felodipine together?
- Can I take Magnesium and Oestrogel pump-pack together?
- Can I take Metformin and Quetiapine together?
- Can I take Oxycodone and Paracetamol together?
- Can I take Sildenafil and Metformin together?