Can I take Lercanidipine and Vitamin D3 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known interaction between lercanidipine and vitamin D3 (cholecalciferol). It is generally safe to take these two together.
Why this happens
Lercanidipine is a calcium channel blocker used for high blood pressure, and vitamin D3 helps the body absorb calcium for bone health. While they both involve calcium pathways, they work in different ways and do not interfere with each other's absorption or breakdown in the body.
What you should do
You can continue taking both as prescribed. It is always a good idea to inform your doctor or pharmacist of all supplements you are taking, but no special precautions are needed for this combination.
Important precautions
Severe liver or kidney disease
Lercanidipine is not recommended if you have severe liver or kidney problems. Ensure your doctor is aware of your condition before starting treatment.
Hypercalcaemia (high blood calcium levels)
Do not take vitamin D3 if you have high levels of calcium in your blood or urine, as this supplement will further increase these levels and may cause kidney damage.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol while taking lercanidipine. Alcohol can increase the blood-pressure-lowering effect of the medicine, which may make you feel dizzy, lightheaded, or faint.
Grapefruit and grapefruit juice
You must not eat grapefruit or drink grapefruit juice while taking lercanidipine. Grapefruit can significantly increase the amount of the medicine in your blood, making side effects like dizziness, headaches, and a fast heartbeat much more likely.
High-fat meals
Lercanidipine should be taken at least 15 minutes before a meal. Taking it with or immediately after a high-fat meal can significantly increase the amount of medicine absorbed by your body, which may lead to more side effects.
Vitamin D is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Warfarin and Ibuprofen together?
Taking ibuprofen while on warfarin significantly increases your risk of serious bleeding, particularly in the stomach or gut. This combination can cause internal bleeding that may be difficult to stop.

Drug interactions checker
Can I take Mounjaro and Insulin together?
Taking Mounjaro (tirzepatide) and insulin together significantly increases your risk of having a 'hypo' (hypoglycaemia), which is when your blood sugar levels drop too low. Symptoms of a hypo can include feeling shaky, sweaty, dizzy, hungry, or confused. In severe cases, it can be dangerous.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Allopurinol and Mirtazapine together?
- Can I take Amlodipine and Lansoprazole together?
- Can I take Amlodipine and Ramipril together?
- Can I take Ashwagandha and Sertraline together?
- Can I take Aspirin and Doxazosin together?
- Can I take Aspirin and Tramadol together?
- Can I take Atenolol and Co-amoxiclav together?
- Can I take Atorvastatin and Matcha together?
- Can I take Glucosamine and Magnesium together?
- Can I take Levothyroxine and Felodipine together?
- Can I take Lisinopril and Potassium together?
- Can I take Losartan and Pregabalin together?
- Can I take Magnesium and Vitamin D together?
- Can I take Mounjaro and Paracetamol together?
- Can I take Oestrogel pump-pack and Vitamin B2 together?
- Can I take Prozac and Wellbutrin together?
- Can I take St John's wort and Vitamin B12 together?
- Can I take Vitamin B complex and Vitamin C together?
- Can I take Vitamin C and Turmeric with black pepper together?