Can I take Esomeprazole and Pregabalin together?
Drug interaction guide
Originally published 25 Jan 2026
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There are no known significant interactions between esomeprazole and pregabalin. It is generally considered safe to take these two medications together.
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Why this happens
Esomeprazole (a proton pump inhibitor) and pregabalin (a gabapentinoid) are processed by different pathways in the body. Esomeprazole is primarily broken down by liver enzymes, while pregabalin is mostly removed from the body unchanged by the kidneys. They do not interfere with each other's absorption or effectiveness.
What you should do
You can take both medications as prescribed by your doctor. You do not need to change the timing of your doses. However, always inform your healthcare provider if you notice any new or unusual side effects when starting a new combination of medicines.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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