Can I take Eplerenone and Paracetamol together?

Why this happens

Eplerenone and paracetamol are processed by different pathways in the body. Eplerenone is a diuretic (water tablet) that works on the kidneys to help with heart conditions, while paracetamol is a painkiller processed mainly by the liver. They do not interfere with how each other works or how they are cleared from the system.

You can take paracetamol while using eplerenone. Always follow the dosage instructions on the packet for paracetamol and do not exceed the maximum daily dose. If you have severe kidney or liver problems, you should always check with your doctor before taking any new medicines.

High potassium levels (hyperkalaemia)

Eplerenone can cause dangerously high levels of potassium in your blood. You must avoid using potassium supplements or salt substitutes containing potassium (such as Lo-Salt) while taking this medicine.

Kidney disease

You must not take eplerenone if you have severe kidney disease, as this significantly increases the risk of life-threatening potassium build-up.

Liver disease

You must not exceed the maximum dose of paracetamol, as this can cause serious liver damage. If you have existing liver problems, you must speak to your doctor before use.

Combination products

Many over-the-counter cold and flu remedies also contain paracetamol. Taking more than one product containing paracetamol can lead to a fatal overdose; always check the ingredients of all medicines you are taking.

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. Alcohol can increase the risk of dizziness or fainting with eplerenone. Combining alcohol and paracetamol increases the risk of serious liver damage.

Grapefruit juice

Do not drink grapefruit juice while taking eplerenone. Grapefruit juice can increase the amount of eplerenone in your blood, which significantly increases the risk of side effects.

Salt substitutes (containing potassium)

Avoid using salt substitutes that contain potassium (such as Lo-Salt) or foods very high in potassium (such as bananas, spinach, or coconut water). Eplerenone increases potassium levels in your body; adding more through your diet can lead to dangerously high potassium levels (hyperkalaemia).

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.