Can I take Empagliflozin and Metformin together?

Por qué sucede esto

Both medicines work in different ways to lower your blood sugar. Metformin reduces the amount of sugar your liver produces, while empagliflozin helps your kidneys remove sugar through your urine. Because they both lower blood sugar, their effects are added together. Empagliflozin also causes you to lose more fluid, which can lead to dehydration.

It is very common for these two medicines to be prescribed together (sometimes in a single tablet). You should monitor your blood sugar levels regularly as advised by your doctor. Stay well-hydrated by drinking plenty of water. Seek medical help immediately if you feel very sick, have stomach pain, or notice a fruity smell on your breath, as these can be signs of ketoacidosis.

Dehydration and Diabetic Ketoacidosis (DKA)

You must stop taking empagliflozin and seek urgent medical help if you become very unwell, lose your appetite, or have persistent vomiting/diarrhoea. This is to prevent a rare but serious condition called ketoacidosis, which can occur even if your blood sugar levels are normal.

Severe illness, dehydration, or excessive alcohol intake

You must stop taking metformin and seek urgent medical help if you experience severe vomiting, diarrhoea, or high fever. These can lead to lactic acidosis, a rare but life-threatening build-up of acid in the blood.

Fournier’s gangrene - empagliflozin

Seek immediate medical attention if you experience severe pain, tenderness, redness, or swelling in the genital or anal area, accompanied by fever or a general feeling of being unwell.

Surgery or medical procedures

You must inform your surgeon or dentist you are taking these medicines. Empagliflozin usually needs to be stopped at least 3 days before major surgery to prevent ketoacidosis, and metformin may need to be paused if you are having an X-ray or scan involving iodine contrast.

Foot ulcers

Check your feet regularly and tell your doctor immediately if you develop any sores, ulcers, or infections, as empagliflozin may increase the risk of lower limb amputations if foot care is neglected.

Alcohol

It is best to avoid or strictly limit alcohol when taking these medicines. For Metformin, alcohol increases the risk of a rare but serious condition called lactic acidosis. For Empagliflozin, alcohol can increase the risk of diabetic ketoacidosis (DKA) and dehydration. Alcohol also makes it harder to manage your blood sugar levels.

Water and fluids

It is essential to drink plenty of water and stay well-hydrated. Empagliflozin works by removing sugar through your urine, which increases the amount of fluid you lose. This can lead to dehydration and low blood pressure if you do not drink enough fluids.

General food advice

Metformin should be taken with or immediately after a meal. This helps to reduce common side effects such as stomach upset, nausea, and diarrhoea.

Absorción de vitamina B12

El uso prolongado de metformina puede impedir que su cuerpo absorba suficiente vitamina B12 de los alimentos. Es posible que necesite que su médico controle sus niveles de B12 o que tome un suplemento si desarrolla síntomas como fatiga extrema o una lengua dolorida.

Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.