Can I take Co-codamol and Clopidogrel together?
Guía de interacción de medicamentos
Publicado originalmente 25 Ene 2026
Cumple con las directrices editoriales
- DescargarDescargar
- Compartir
- Language
- Discusión
- Versión en audio
Taking co-codamol (which contains codeine) alongside clopidogrel may make the clopidogrel less effective at preventing blood clots. This could potentially increase your risk of having a heart attack or stroke.
En este artículo:
Video picks for Interacciones de medicamentos
Continúa leyendo abajo
Por qué sucede esto
Clopidogrel needs to be broken down by the body to start working. Codeine (in co-codamol) can slow down the movement of your gut and interfere with how clopidogrel is absorbed and processed, meaning there is less of the active medicine in your bloodstream to thin your blood.
Lo que deberías hacer
Volver al contenidoYou should speak to your doctor or pharmacist before taking these together. They may suggest an alternative painkiller that does not interfere with your heart medication, such as paracetamol on its own. If you must take both, your doctor may need to monitor you more closely.
Continúa leyendo abajo
Precauciones importantes
Volver al contenidosobredosis de paracetamol
Co-codamol contains paracetamol. Do not take it with any other paracetamol-containing products (such as cold and flu remedies), as this can lead to fatal liver damage.
Adicción a los opioides y abstinencia
Co-codamol contains codeine, which can cause addiction if used for more than 3 days. Stopping suddenly after long-term use can cause withdrawal symptoms.
Dificultades respiratorias
No tome co-codamol si tiene asma severa o problemas respiratorios, ya que la codeína puede ralentizar peligrosamente su respiración.
Active bleeding
Do not take clopidogrel if you have an active bleeding site, such as a stomach ulcer or bleeding in the brain, as it prevents blood clotting and will worsen the condition.
Upcoming surgery or dental work
You must tell your surgeon or dentist you are taking clopidogrel at least 7 days before any planned procedure, as it increases your risk of bleeding and may need to be stopped temporarily.
Advertencias sobre alimentos y bebidas
Volver al contenidoAlcohol
You must avoid drinking alcohol while taking co-codamol. Combining alcohol with codeine increases the risk of serious side effects, such as extreme sleepiness, breathing difficulties, and loss of consciousness. Additionally, both alcohol and paracetamol can affect the liver; combining them regularly increases the risk of liver damage.
It is best to avoid or strictly limit alcohol while taking clopidogrel. Both alcohol and clopidogrel can irritate the stomach lining and increase the risk of internal bleeding, particularly in the stomach and intestines.
Jugo de toronja
Grapefruit juice can interfere with how your body processes codeine, potentially making the medicine less effective or increasing the risk of side effects. It is best to avoid grapefruit juice while taking this medicine.
Grapefruit juice can reduce the effectiveness of clopidogrel, making it less likely to prevent blood clots. It is best to avoid drinking grapefruit juice or eating grapefruit while taking this medicine.
Cafeína
Some versions of co-codamol already contain caffeine. If you consume extra caffeine from coffee, tea, or energy drinks, it may make you feel shaky, anxious, or cause a racing heart.
Continúa leyendo abajo
Uso de otros medicamentos
Volver al contenidoTaking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.
Patient picks for Interacciones de medicamentos

Verificador de interacciones de medicamentos
Can I take antihistamines with asthma?
While antihistamines are generally safe for people with asthma, older 'sedating' antihistamines (like chlorphenamine) can occasionally make asthma symptoms harder to manage by drying out the airways. Additionally, some people with asthma may have a higher risk of allergic reactions to certain ingredients in liquid medications.

Verificador de interacciones de medicamentos
¿Puedo tomar Cannabis y Paracetamol juntos?
No se conocen interacciones significativas entre el cannabis y el paracetamol. Generalmente se considera seguro usarlos juntos en las dosis recomendadas.
Continúa leyendo abajo
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
25 Ene 2026 | Publicado originalmente

Pregunta, comparte, conecta.
Navega por discusiones, haz preguntas y comparte experiencias en cientos de temas de salud.

¿Te sientes mal?
Evalúa tus síntomas en línea de forma gratuita
Suscríbete al boletín de Patient
Tu dosis semanal de consejos de salud claros y confiables, escritos para ayudarte a sentirte informado, seguro y en control.
By subscribing you accept our Política de Privacidad. Puedes darte de baja en cualquier momento. Nunca vendemos tus datos.