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Can I take Co-codamol and Clopidogrel together?

Guía de interacción de medicamentos

Taking co-codamol (which contains codeine) alongside clopidogrel may make the clopidogrel less effective at preventing blood clots. This could potentially increase your risk of having a heart attack or stroke.

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Por qué sucede esto

Clopidogrel needs to be broken down by the body to start working. Codeine (in co-codamol) can slow down the movement of your gut and interfere with how clopidogrel is absorbed and processed, meaning there is less of the active medicine in your bloodstream to thin your blood.

You should speak to your doctor or pharmacist before taking these together. They may suggest an alternative painkiller that does not interfere with your heart medication, such as paracetamol on its own. If you must take both, your doctor may need to monitor you more closely.

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sobredosis de paracetamol

Co-codamol contains paracetamol. Do not take it with any other paracetamol-containing products (such as cold and flu remedies), as this can lead to fatal liver damage.

Adicción a los opioides y abstinencia

Co-codamol contains codeine, which can cause addiction if used for more than 3 days. Stopping suddenly after long-term use can cause withdrawal symptoms.

Dificultades respiratorias

No tome co-codamol si tiene asma severa o problemas respiratorios, ya que la codeína puede ralentizar peligrosamente su respiración.

Active bleeding

No tome clopidogrel if you have an active bleeding site, such as a stomach ulcer or bleeding in the brain, as it prevents blood clotting and will worsen the condition.

Upcoming surgery or dental work

You must tell your surgeon or dentist you are taking clopidogrel at least 7 days before any planned procedure, as it increases your risk of bleeding and may need to be stopped temporarily.

Alcohol

You must avoid drinking alcohol while taking co-codamol. Combining alcohol with codeine increases the risk of serious side effects, such as extreme sleepiness, breathing difficulties, and loss of consciousness. Additionally, both alcohol and paracetamol can affect the liver; combining them regularly increases the risk of liver damage.

It is best to avoid or strictly limit alcohol while taking clopidogrel. Both alcohol and clopidogrel can irritate the stomach lining and increase the risk of internal bleeding, particularly in the stomach and intestines.

Jugo de toronja

Grapefruit juice can interfere with how your body processes codeine, potentially making the medicine less effective or increasing the risk of side effects. It is best to avoid grapefruit juice while taking this medicine.

Grapefruit juice can reduce the effectiveness of clopidogrel, making it less likely to prevent blood clots. It is best to avoid drinking grapefruit juice or eating grapefruit while taking this medicine.

Cafeína

Some versions of co-codamol already contain caffeine. If you consume extra caffeine from coffee, tea, or energy drinks, it may make you feel shaky, anxious, or cause a racing heart.

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Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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