Can I take Chaga and Royal sun together?
Drug interaction guide
Originally published 24 Jan 2026
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Both Chaga (Inonotus obliquus) and Royal Sun (Agaricus blazei) are medicinal mushrooms that can lower blood sugar levels and thin the blood. Taking them together may increase the risk of your blood sugar dropping too low (hypoglycaemia) or increase the risk of bruising and bleeding.
Why this happens
These mushrooms have additive effects. Both contain compounds (like beta-glucans) that improve insulin sensitivity and others that may interfere with blood clotting (anti-platelet effects). Taking them together doubles up on these specific actions.
What you should do
Use this combination with caution. If you have diabetes or take blood-thinning medication (like warfarin or aspirin), you must speak to your doctor before combining these supplements. Monitor your blood sugar levels closely and watch for signs of easy bruising or nosebleeds. Stop taking both at least two weeks before any scheduled surgery.
Important precautions
Kidney disease or history of kidney stones
Chaga is extremely high in oxalates, which can cause permanent kidney damage or acute kidney failure, especially in those with existing renal issues.
Diabetes
Both mushrooms can significantly lower blood glucose levels. Using them alongside prescribed diabetes medication increases the risk of severe hypoglycaemia (dangerously low blood sugar).
Autoimmune diseases (e.g., Lupus, MS, Rheumatoid Arthritis)
Chaga can stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications.
Bleeding disorders or upcoming surgery
Chaga may slow blood clotting and increase the risk of bleeding; it should be avoided if you have a bleeding disorder or are scheduled for surgery.
Food and drink warnings
Alcohol
Chaga contains high levels of oxalates. Combining it with alcohol may increase the risk of kidney stones or kidney stress, as both substances can affect renal function. Use with caution.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
24 Jan 2026 | Originally published

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