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Can I take Atorvastatin and Shiitake together?

Guía de interacción de medicamentos

Taking shiitake mushrooms (especially in concentrated supplement form) alongside atorvastatin may increase the risk of muscle-related side effects, such as muscle aches, weakness, or tenderness. In rare cases, this could lead to a more serious condition called rhabdomyolysis, which can damage the kidneys.

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Generalmente puedes tomar atorvastatina with shiitake mushrooms if you occasionally eat them as part of a normal diet. However, you should avoid taking concentrated shiitake supplements or large medicinal amounts without speaking to your doctor first.

Shiitake mushrooms naturally contain a substance called eritadenine, which helps lower cholesterol. They also contain small amounts of naturally occurring statin-like compounds (similar to lovastatin).

When taken with atorvastatin, these effects can add together (an additive effect), potentially increasing the level of statin activity in your body beyond what was intended by your prescription.

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Lo que deberías hacer

If you experience any unexplained muscle pain, tenderness, or weakness while taking these together, contact your GP immediately.

Embarazo

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Blood clotting disorders or surgery

Shiitake supplements can thin the blood and increase the risk of bleeding. You must stop taking them at least two weeks before any scheduled surgery.

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Jugo de toronja

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

While alcohol does not directly interact with atorvastatin, drinking large amounts of alcohol can increase the risk of liver problems and muscle side effects. It is best to keep your intake within the recommended limits (no more than 14 units per week).

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Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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