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Can I take Atorvastatin and Lixiana together?

Drug interaction guide

There is no direct interaction between atorvastatin and Lixiana (edoxaban). However, both medications can increase the risk of bleeding in different ways. While Lixiana is a blood thinner that directly prevents clots, atorvastatin can occasionally cause side effects that might complicate your treatment.

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Why this happens

Atorvastatin is processed by a specific liver enzyme (CYP3A4), while Lixiana is mainly cleared by the kidneys and a transport protein (P-gp). Because they use different pathways, they do not interfere with how the body absorbs or breaks down the other. There is a very rare risk that statins can cause muscle breakdown, which can affect kidney function; if kidneys are affected, Lixiana levels could potentially rise, though this is extremely unlikely.

What you should do

You can safely take these two medicines together as prescribed. You should monitor for any unusual bruising or bleeding (such as nosebleeds or bleeding gums). If you experience unexplained muscle pain, tenderness, or weakness, contact your doctor, as this is a known side effect of statins that requires monitoring.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Historia del artículo

La información de esta página ha sido redactada y revisada por médicos cualificados.

  • 25 Enero 2026 | Publicado originalmente
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