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Can I take Amoxicillin and Sertraline together?

Guía de interacción de medicamentos

There is no known direct interaction between amoxicillin and sertraline. It is generally considered safe to take these two medications together.

It is generally considered safe to take amoxicillin y sertralina together.

Amoxicillin is an antibiotic cleared by the kidneys, while sertraline is an antidepressant processed by the liver. They do not interfere with each other's absorption, metabolism, or effects on the body.

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How to take amoxicillin and sertraline safely

  • Take both medications as prescribed by your doctor.

  • Be aware that both medications can sometimes cause side effects such as diarrhoea or an upset stomach.

  • If you experience severe diarrhoea while taking the antibiotic, contact your GP.

Trastornos de depresión y ansiedad

Es posible que experimente un aumento en los pensamientos suicidas o el impulso de autolesionarse al comenzar a tomar sertralina o al cambiar la dosis. Esto es más frecuente en adultos jóvenes menores de 25 años. Comuníquese con su médico o acuda a un hospital de inmediato si nota cambios en su estado de ánimo o comportamiento.

Penicillin allergy

Do not take amoxicillin if you have ever had an immediate allergic reaction (such as a rash, swelling, or breathing difficulties) to any penicillin or cephalosporin antibiotic, as this can cause a life-threatening reaction.

Serotonin syndrome risk

Do not take sertraline if you are taking, or have taken in the last 14 days, an MAOI antidepressant (such as phenelzine or selegiline), as this can cause a dangerous and potentially fatal rise in serotonin levels.

Aumento del riesgo de sangrado

Be aware that sertraline increases your risk of internal bleeding, especially if you also take aspirin, ibuprofen, or blood-thinning medications like warfarin.

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Alcohol

It is best to avoid drinking alcohol while taking sertraline. Alcohol can increase the sedative effects of the medicine, making you feel more sleepy, dizzy, or uncoordinated.

It is best to avoid or strictly limit alcohol while taking amoxicillin. While there is no direct chemical interaction, alcohol can dehydrate you and interfere with your sleep, which may slow down your recovery from infection. Additionally, both alcohol and amoxicillin can cause stomach upset or nausea, and combining them may make these side effects worse.

Jugo de toronja

Avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that can increase the level of sertraline in your blood, which may increase the risk of side effects.

Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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