Can I take Amitriptyline and Pregabalin together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amitriptyline and pregabalin together can make you feel very sleepy, dizzy, and unsteady on your feet. It can also cause significant confusion, difficulty concentrating, and may slow down your breathing.
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Why this happens
Both medicines work by slowing down activity in the central nervous system. When used together, their sedative effects add up (an additive effect), making the side effects much stronger than if you took either medicine alone.
What you should do
Use this combination with caution. Do not drive, cycle, or operate heavy machinery until you know how these medicines affect you. Avoid drinking alcohol, as it will make the sleepiness much worse. If you feel extremely drowsy or have trouble breathing, seek medical help immediately. Your doctor may need to adjust your doses.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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