Can I take Amitriptyline and Naproxen bp together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking amitriptyline and naproxen together can increase your risk of developing a stomach ulcer or experiencing internal bleeding, particularly in the stomach or intestines. It may also slightly increase the risk of bleeding elsewhere in the body.
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Why this happens
Amitriptyline belongs to a group of medicines that can affect how your blood platelets work. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that also thins the blood slightly and can irritate the lining of the stomach. When used together, these effects add up, making bleeding more likely.
What you should do
You can take these together if prescribed by your doctor, but you should be vigilant. Seek medical advice immediately if you notice signs of bleeding, such as vomit that looks like coffee grounds, very dark or 'tarry' stools, or unexplained bruising. If you need to take this combination long-term, your doctor may prescribe a 'stomach protector' medicine (like omeprazole) to reduce the risk.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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