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Can I take Alogliptin and Empagliflozin together?

Guía de interacción de medicamentos

Taking alogliptin and empagliflozin together can increase the risk of your blood sugar levels dropping too low (hypoglycaemia). While both drugs are designed to lower blood sugar, using them at the same time has an additive effect. You may also have a slightly higher risk of dehydration or urinary tract infections.

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Por qué sucede esto

Both medicines work in different ways to lower blood glucose: alogliptin increases insulin production after meals, while empagliflozin helps the kidneys remove sugar through urine. Because they both lower blood sugar, their combined effect is stronger than taking either one alone.

It is common for these two medicines to be prescribed together, but you should monitor your blood sugar levels regularly as directed by your doctor. Learn to recognise the signs of low blood sugar (such as feeling shaky, sweaty, hungry, or dizzy) and always carry a quick-acting sugar source, like glucose tablets or a sugary drink. Ensure you drink plenty of water to stay hydrated.

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Diabetic Ketoacidosis (DKA)

Empagliflozin can cause a serious condition called ketoacidosis even if your blood sugar levels are near normal. Seek immediate medical help if you experience nausea, vomiting, stomach pain, or fruity-smelling breath. Stop taking this medicine if you are fasting for surgery or have a severe illness.

Fournier’s gangrene - empagliflozin

Seek urgent medical attention if you experience pain, tenderness, redness, or swelling in the genital or anal area, especially if accompanied by fever or a general feeling of being unwell.

Acute Pancreatitis

Stop taking alogliptin and contact your doctor immediately if you experience severe and persistent stomach pain, which might reach through to your back, as this may be a sign of an inflamed pancreas.

Alcohol

Drinking alcohol with these medicines can increase the risk of low blood sugar (hypoglycaemia) and, in the case of empagliflozin, may increase the risk of a rare but serious condition called ketoacidosis. It is best to avoid excessive alcohol consumption and never drink on an empty stomach.

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Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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