collagen type I alpha 1 chain
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El COL1A1 gene provides instructions for making part of a large molecule called type I collagen. Collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon, skin, and the white part of the eye (the sclera). Type I collagen is the most abundant form of collagen in the human body.
Normal function
El COL1A1 gene provides instructions for making part of a large molecule called type I collagen. Collagens are a family of proteins that strengthen and support many tissues in the body, including cartilage, bone, tendon, skin, and the white part of the eye (the sclera). Type I collagen is the most abundant form of collagen in the human body.
A component of type I collagen called the pro-α1(I) chain is produced from the COL1A1 gene. Collagens begin as rope-like procollagen molecules that are each made up of three chains. Type I collagen is composed of two pro-α1(I) chains and one pro-α2(I) chain (which is produced from the COL1A2 gene).
The triple-stranded procollagen molecules are processed by enzymes in a series of steps inside and outside the cell to create mature collagen. The collagen molecules then arrange themselves into long, thin fibrils that form stable interactions (cross-links) with one another in the spaces between cells. The cross-links result in the formation of very strong type I collagen fibers.
Conditions referring to this gene or chromosome
Otros nombres
alpha 1 type I collagen preproprotein
CO1A1_HUMAN
COL1A1 protein
collagen I, alpha-1 polypeptide
collagen of skin, tendon and bone, alpha-1 chain
collagen type I alpha 1
collagen, type I, alpha 1
type I collagen alpha 1
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Lecturas adicionales y referencias
- collagen type I alpha 1 chain; MedlinePlus, National Library of Medicine.
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