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Can I take Diazepam and Codeine together?

Guía de interacción de medicamentos

Taking diazepam and codeine together can cause extreme sleepiness, dizziness, and severe breathing difficulties. In serious cases, this combination can lead to a coma or be life-threatening because it can cause you to stop breathing.

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Por qué sucede esto

Both medicines are 'central nervous system depressants'. This means they both slow down brain activity and the signals that tell your body to breathe. When taken together, their effects add up, making the impact on your breathing and alertness much stronger than if taken alone.

You should only take these two medicines together if they have been specifically prescribed by the same doctor who is aware you are taking both. If you must take both, use the lowest dose possible for the shortest amount of time. Seek emergency medical help immediately if you experience extreme sleepiness, shallow breathing, or difficulty staying awake. Avoid alcohol completely while taking these medicines.

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Combined use with other sedatives or alcohol

Taking these medicines together, or with alcohol, significantly increases the risk of life-threatening breathing problems and extreme sleepiness. Avoid alcohol and do not take other sedating medicines unless specifically directed by your doctor.

Ultra-rapid metabolism (CYP2D6)

Some people turn codeine into morphine much faster than normal. If you experience extreme sleepiness, confusion, or shallow breathing, stop taking the medicine and seek urgent medical help. This is especially dangerous for breastfeeding mothers as it can cause fatal overdose in the baby.

Long-term use and dependence

These medicines are for short-term use only. Taking them for more than a few days can lead to physical addiction and withdrawal symptoms when you stop. Do not increase the dose or take them for longer than prescribed.

Asma o problemas respiratorios

No tome codeína si tiene asma severa o dificultades para respirar, ya que puede disminuir peligrosamente su respiración.

Driving and operating machinery

It is often an offence to drive while taking diazepam as it can seriously impair your coordination and reaction times. Do not drive or operate machinery until you know how this medicine affects you, and always keep the medicine in its original packaging to show the police if stopped.

Depresión respiratoria

Do not take diazepam if you have severe lung disease or breathing difficulties, as it can further slow your breathing to dangerous levels.

Embarazo

Avoid use in late pregnancy or during labour, as it can cause 'floppy infant syndrome' and life-threatening withdrawal symptoms in the newborn.

Alcohol

You must avoid drinking alcohol while taking these medicines. Both diazepam and codeine cause drowsiness and slow down your breathing. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and loss of consciousness.

Jugo de toronja

Avoid drinking large amounts of grapefruit juice. Grapefruit contains compounds that can stop your body from breaking down diazepam properly. This can lead to higher levels of the medicine in your blood, increasing the risk of side effects like extreme sleepiness and poor coordination.

Cafeína (Café, té, bebidas energéticas)

Caffeine is a stimulant and can have the opposite effect of diazepam, which is a sedative. Consuming high amounts of caffeine may make diazepam less effective at treating anxiety or helping you sleep.

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Taking multiple medicines? Our Verificador de Interacciones de Medicamentos helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • 25 Ene 2026 | Publicado originalmente
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