Can I take Colecalciferol and Prednisolone together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking prednisolone can lower the levels of vitamin D (colecalciferol) in your body, making the vitamin D supplement less effective. Over time, this can lead to weaker bones.
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Why this happens
Prednisolone is a steroid medication that interferes with how your body processes vitamin D. It can speed up the breakdown of vitamin D and also reduce how much calcium your body absorbs from your food, which vitamin D normally helps with.
What you should do
You can take these medicines together, but your doctor may need to monitor your vitamin D and calcium levels with blood tests. In some cases, a higher dose of colecalciferol or an additional calcium supplement may be recommended to protect your bone health while you are taking steroids.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente
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