Can I take Co-codamol and Omeprazole together?
Guía de interacción de medicamentos
Publicado originalmente 25 Ene 2026
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There is no direct harmful interaction between co-codamol and omeprazole. However, co-codamol contains codeine, which can cause constipation. Omeprazole is used to reduce stomach acid and does not typically affect how co-codamol works.
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Por qué sucede esto
These two medications are processed by different pathways in the body. Omeprazole works on the acid-producing pumps in the stomach, while co-codamol (a mix of paracetamol and codeine) works on pain receptors and the central nervous system. They do not significantly interfere with each other's absorption or metabolism.
Lo que deberías hacer
Volver al contenidoIt is safe to take these two medications together. If you find that the codeine in the co-codamol causes constipation, ensure you drink plenty of water and eat high-fibre foods. If you have any concerns about your stomach health or persistent pain, speak with your pharmacist or GP.
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Precauciones importantes
Volver al contenidosobredosis de paracetamol
Co-codamol contains paracetamol. Do not take it with any other paracetamol-containing products (such as cold and flu remedies), as this can lead to fatal liver damage.
Adicción a los opioides y abstinencia
Co-codamol contains codeine, which can cause addiction if used for more than 3 days. Stopping suddenly after long-term use can cause withdrawal symptoms.
Dificultades respiratorias
No tome co-codamol si tiene asma severa o problemas respiratorios, ya que la codeína puede ralentizar peligrosamente su respiración.
Diarrea severa
Omeprazole can increase the risk of serious stomach infections (like C. difficile). Contact your doctor immediately if you develop severe or persistent watery diarrhoea.
Lupus-like skin reactions - omeprazole
Seek medical advice if you develop a skin rash, especially in areas exposed to the sun, as this may be a sign of subacute cutaneous lupus erythematosus (SCLE).
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Volver al contenidoAlcohol
You must avoid drinking alcohol while taking co-codamol. Combining alcohol with codeine increases the risk of serious side effects, such as extreme sleepiness, breathing difficulties, and loss of consciousness. Additionally, both alcohol and paracetamol can affect the liver; combining them regularly increases the risk of liver damage.
It is best to avoid or strictly limit alcohol while taking omeprazole. Alcohol can increase the amount of acid your stomach produces, which may worsen your symptoms or make the medicine less effective. Additionally, both alcohol and omeprazole can irritate the stomach lining.
Jugo de toronja
Grapefruit juice can interfere with how your body processes codeine, potentially making the medicine less effective or increasing the risk of side effects. It is best to avoid grapefruit juice while taking this medicine.
Cafeína
Some versions of co-codamol already contain caffeine. If you consume extra caffeine from coffee, tea, or energy drinks, it may make you feel shaky, anxious, or cause a racing heart.
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Uso de otros medicamentos
Volver al contenido¿Tomas múltiples medicamentos? Nuestro Verificador de Interacciones de Medicamentos te ayuda a verificar si tus recetas, medicamentos de venta libre y suplementos son seguros para tomar juntos. Simplemente busca tus medicamentos para ver posibles interacciones y qué hacer al respecto.
Descargo de responsabilidad
Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
25 Ene 2026 | Publicado originalmente

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