Can I take Atorvastatin and Spironolactone together?
Drug interaction guide
Originally published 25 Jan 2026
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Taking these two medicines together can occasionally lead to a build-up of potassium in your blood (hyperkalaemia). While both drugs are often prescribed together safely, they can both influence how your body handles minerals and muscle health. There is also a very small increased risk of muscle-related side effects.
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Why this happens
Spironolactone is a 'potassium-sparing' diuretic that prevents your body from flushing out potassium. While atorvastatin does not directly affect potassium, some studies suggest that statins may occasionally interfere with how the kidneys manage minerals, or in rare cases of muscle breakdown (rhabdomyolysis), potassium levels can rise sharply.
What you should do
It is generally safe to take these together if prescribed by your doctor, but you should have regular blood tests to check your potassium levels and kidney function. Seek medical advice if you experience unexplained muscle pain, tenderness, or weakness, or if you feel heart palpitations or unusual tiredness.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Descargo de responsabilidad
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
25 Enero 2026 | Publicado originalmente

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