Can I take Aspirin and Spironolactone together?

Why this happens

Spironolactone works by helping your kidneys get rid of salt and water. Aspirin can block the chemical signals (prostaglandins) that the kidneys need to do this job effectively. Additionally, both drugs can affect how the kidneys filter blood, which can lead to a buildup of potassium or reduced kidney function.

What you should do

Use this combination with caution. If you are taking aspirin for pain relief, consider using paracetamol instead. If you are taking low-dose aspirin (75mg to 150mg) for heart protection, do not stop taking it, but ensure your doctor monitors your kidney function and potassium levels regularly. Seek medical advice if you notice swelling in your ankles or a decrease in how much you urinate.

Important precautions

Asthma

Do not take aspirin if you have a history of asthma, as it can trigger a severe or life-threatening asthma attack.

High potassium levels (Hyperkalaemia)

Avoid using potassium supplements or salt substitutes containing potassium. Spironolactone can cause potassium levels to rise dangerously high, which can affect your heart rhythm.

Pregnancy (third trimester)

Do not take aspirin during the last three months of pregnancy as it can cause serious heart and kidney problems in the unborn baby and increase the risk of bleeding during delivery.

Food and drink warnings

Alcohol

Drinking alcohol while taking aspirin can increase the risk of stomach irritation and bleeding. It is best to limit alcohol intake or avoid it if you have a history of stomach issues.

Foods high in potassium (e.g., bananas, oranges, leafy greens, salt substitutes)

Spironolactone is a 'potassium-sparing' diuretic. Consuming large amounts of potassium-rich foods or using salt substitutes (which often contain potassium chloride) can lead to dangerously high levels of potassium in your blood (hyperkalaemia).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.