Can I take Amlodipine and Simvastatin together?

Por qué sucede esto

Amlodipine interferes with a specific enzyme in your liver (called CYP3A4) that is responsible for breaking down simvastatin. Because the enzyme is busy dealing with the amlodipine, it cannot clear the simvastatin as quickly as usual, leading to higher levels of the statin in your body.

You can take these medicines together, but your doctor must limit your dose of simvastatin. In the UK, it is recommended that patients taking amlodipine should not take more than 20mg of simvastatin daily. If you are currently prescribed a higher dose (such as 40mg or 80mg), speak to your doctor about adjusting your prescription. Seek medical advice immediately if you develop unexplained muscle pain or dark-coloured urine.

Embarazo

You must not take simvastatin if you are pregnant or planning to become pregnant, as it may harm the developing baby. Use effective contraception while taking this medicine.

Grapefruit consumption

Avoid drinking large amounts of grapefruit juice. Grapefruit increases the level of these medicines in your blood, which significantly raises your risk of serious side effects like muscle damage.

Muscle pain or weakness - simvastatin

Report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Jugo de toronja

Grapefruit juice can increase the amount of these medicines in your blood, which makes side effects more likely. For simvastatin, you should avoid grapefruit juice completely. For amlodipine, you should avoid drinking large amounts of it.

Alcohol

Drinking large amounts of alcohol while taking simvastatin can increase your risk of liver problems and muscle side effects. It is best to keep your intake within the recommended low-risk limits.

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Descargo de responsabilidad

Esta información es solo para fines educativos generales y no debe considerarse como un sustituto del consejo médico profesional. Siempre consulte a su médico de cabecera, farmacéutico u otro profesional de la salud calificado antes de tomar decisiones sobre sus medicamentos. Las circunstancias individuales pueden variar, y solo un profesional de la salud que conozca su historial médico puede proporcionar orientación personalizada.