Pilot trial of omeprazole in idiopathic pulmonary fibrosis (PPIPF Study)
Idiopathic pulmonary fibrosis (IPF) causes progressive scarring in the lungs, often leading to shortness of breath and a persistent, dry cough. Doctors know that acid reflux—where tiny amounts of stomach acid travel up towards the throat and lungs—is very common in people with IPF and may make their cough much worse. This trial is looking at whether omeprazole, a widely used tablet that stops stomach acid production, can help calm this cough. Researchers in Newcastle upon Tyne are comparing omeprazole against a placebo (dummy pill) in adults aged 40 to 85 with IPF. Participants take a capsule twice daily before food for 90 days and attend six hospital visits for simple breathing checks and cough monitoring. The goal is to see if reducing acid provides meaningful relief, which could lead to larger trials and better symptom support.
De un vistazo
¿De qué trata este estudio?
Idiopathic pulmonary fibrosis (IPF) is a lung condition where normal, healthy lung tissue gradually becomes thick and scarred. Over time, this scarring makes it harder for the lungs to take in oxygen, causing breathlessness and a relentless cough. This cough can be exhausting and difficult to treat with standard medicines, significantly affecting a person's quality of life.
In recent years, researchers noticed that many people with IPF also experience acid reflux. Reflux happens when acidic digestive juices leak upwards from the stomach into the food pipe. Even tiny, microscopic droplets of this acid can accidentally enter the airways, irritating the delicate lung tissue and triggering frequent coughing fits.
Omeprazole is an established, gentle medicine that blocks stomach acid production. It has been used safely by millions of people for indigestion. In this study, doctors want to see if switching off stomach acid with omeprazole can calm lung irritation and ease coughing in people with IPF. Because this is a pilot study, it aims to gather early evidence to show whether a larger, nationwide trial should take place.
Puntos clave
- Tests whether the common heartburn drug omeprazole can soothe chronic coughing in IPF.
- Participants take a capsule twice a day for 90 days (either omeprazole or a dummy pill).
- Involves six hospital visits at the Royal Victoria Infirmary in Newcastle upon Tyne.
- Open to adults aged 40 to 85 with a confirmed diagnosis of IPF.
- Participation is voluntary, low-risk, and you can withdraw at any point.
¿Quién puede ser elegible?
This study is designed for adults aged between 40 and 85 who have a confirmed diagnosis of idiopathic pulmonary fibrosis (IPF) agreed by a specialist lung team. Participants must have an ongoing cough, with or without breathlessness during daily activities, alongside typical signs of IPF on chest scans and lung tests.
People who already take acid-reducing tablets (such as omeprazole, lansoprazole, or similar medicines) may still be able to join. However, you might be asked to safely stop taking them for a short time before the study starts. This will only happen if your GP and study doctors agree it is safe for you, and it ensures the trial tests the medicine fairly.
You cannot take part if you have certain severe stomach conditions that strictly require continuous acid medicine, such as Zollinger-Ellison syndrome or a recent history of stomach bleeding.
¿Podría este estudio ser adecuado para ti?
Responde estas preguntas rápidas para ver si puedes ser elegible. Esto es solo una guía: el equipo de investigación toma la decisión final.
- Are you between 40 and 85 years old?
- Have you been diagnosed with idiopathic pulmonary fibrosis (IPF)?
- Do you have a persistent, troublesome cough?
- Are you able to travel to Newcastle for six clinic appointments over three months?
- Are you willing to pause your current indigestion tablets if your GP agrees it is safe?
¿En qué consiste la participación?
Taking part in this study lasts for about three months (90 days). You will be randomly placed into one of two groups by a computer. One group takes a 20 mg omeprazole capsule twice a day before meals, while the other group takes a matching placebo (dummy) capsule. Neither you nor your study doctor will know which one you are taking until the study ends.
You will need to attend six appointments at the Royal Victoria Infirmary in Newcastle upon Tyne. During these visits, the team will check your breathing using routine, non-invasive lung function tests and monitor your cough using safe recording equipment. There are no painful or invasive procedures involved, and the team will closely monitor your wellbeing throughout.
Riesgos y beneficios potenciales
Ubicaciones (1)
- 4th Floor William Leech BuildingSolo ciudadNewcastle Upon Tyne, England
Preguntas comunes
¿Qué es un placebo?
A placebo is a dummy pill that looks and tastes identical to the real medicine but contains no active ingredients. It helps researchers prove whether any improvements are truly caused by the drug.
Will I know if I am taking omeprazole or the dummy pill?
No. This is a double-blind study, which means neither you nor your study team will know which capsule you have until the trial is finished. In a medical emergency, the doctors can quickly find out.
What if I already take indigestion tablets?
You might still be able to join. Your GP and the study team will check if it is safe for you to take a brief, supervised break from your current heartburn tablets before the trial begins.
Does omeprazole cure IPF?
No, omeprazole does not cure IPF or reverse existing lung scars. The goal of this study is simply to see if reducing stomach acid can reduce coughing and improve everyday comfort.
Do I have to pay to take part?
No, the study medication and all trial tests are provided free of charge through the research team and funding from the British Lung Foundation.
Cómo obtener más información
Prosenjit Dutta
Siempre hable con su médico de cabecera o especialista antes de decidir participar en un estudio.
Discusión
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Impulsado por nuestro foro en community.patient.info. Por favor, sea respetuoso — esto no es un consejo médico.