Ranolazine for angina
Ranexa
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 16 Ene 2025
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Ranolazine is one of several medicines you will be prescribed for angina.
Take one tablet twice daily.
Do not drink grapefruit juice while you are on ranolazine.
At a glance
Ranolazine is a medicine used to prevent angina chest pain.
You take it in addition to other angina medicines if your pain is not well controlled.
Take one tablet two times a day, swallowing it whole with water.
Do not drink grapefruit juice while taking ranolazine.
It is not for relieving angina attacks; use your prescribed nitrate medicine for that.
Common side-effects include dizziness, headache, constipation, and feeling sick.
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About ranolazine for angina
Tipo de medicamento | An anti-anginal medicine |
Usado para | To prevent angina chest pain |
También llamado | Ranexa®, Ranogelan®, Anzipro® |
Disponible como | Comprimidos |
Angina is a pain that comes from the heart. It is usually caused by the narrowing of one or more of the arteries that supply blood to your heart. This narrowing reduces the blood supply to parts of your heart muscle. When your heart needs more blood and oxygen than it can get through the narrowed arteries (for example, when you walk fast or climb stairs), you feel angina pain.
Ranolazine is taken in addition to other medicines used to prevent angina pain. You will be prescribed it if the other anti-anginal medicines you are taking are not sufficiently controlling your chest pains.
Before taking ranolazine
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking ranolazine it is important that your doctor knows:
Si estás embarazada o amamantando.
If you know you have an irregular heart rhythm.
If you have been told you have heart failure, which is a condition where your heart is not working as well as it should.
Si tienes algún problema con el funcionamiento de tu hígado, o algún problema con el funcionamiento de tus riñones.
Si alguna vez has tenido una reacción alérgica a un medicamento.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
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How to take ranolazine
Volver al contenidoBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about ranolazine and will also provide you with a full list of side-effects which you could experience from taking it.
Take ranolazine exactly as your doctor tells you to. It is usual to take one tablet two times a day. When starting your treatment your doctor will give you a smaller-strength tablet (375 mg tablet) and may then gradually increase your dose to a 500 mg or a 750 mg strength of tablet. This allows your doctor to make sure that you have the dose that helps your condition but avoids any unwanted symptoms.
Try to take your doses at the same times of day each day, as this will help you to remember to take them regularly. You can take ranolazine either before or after a meal. Swallow the tablet whole (without chewing or crushing it) with a drink of water.
If you forget to take a dose at your usual time, take it when you remember. However, if it is nearly time to take your next dose then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoRanolazine tablets are not suitable to take to relieve pain if you are having an angina attack. Your doctor will also prescribe a nitrate medicine, such as glyceryl trinitrate (GTN), for you to take if this happens. If after using GTN your pain has not eased within a few minutes, call for an ambulance.
Intenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
Treatment with ranolazine is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise by your doctor.
Do not drink grapefruit juice while you are on ranolazine. This is because a chemical in grapefruit juice increases the amount of ranolazine in your bloodstream. This makes side-effects more likely.
It is important if you buy any medicines 'over the counter' to check with a pharmacist that they are suitable for you to take. Some medicines and herbal remedies should not be taken with ranolazine.
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Can ranolazine cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with ranolazine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common ranolazine side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Feeling dizzy or weak | Do not drive and do not use tools or machines while affected. Please let your doctor know about any dizziness as your dose may need adjusting |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico |
Estreñimiento | Come una dieta equilibrada y bebe mucha agua |
Sentirse mal (náuseas) o estar enfermo (vómitos) | Eat simple meals - avoid rich or spicy food. If this continues let your doctor know as your dose may need adjusting |
Si experimenta cualquier otro síntoma que crea que puede deberse a las tabletas, hable con su médico o farmacéutico para obtener más consejos.
How to store ranolazine
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine go to the accident and emergency department of your local hospital at once. Take the container with you, even if it is empty.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
Can ranolazine cure my angina?
No, ranolazine is used to prevent angina chest pain by improving the blood supply to your heart muscle. It does not cure angina, but helps manage the symptoms.
Why would my doctor prescribe ranolazine if I'm already taking other medicines for angina?
Your doctor will prescribe ranolazine if the other anti-anginal medicines you are already taking are not sufficiently controlling your chest pains. It is taken in addition to your existing treatments.
What should I do if I feel dizzy or weak after taking ranolazine?
If you feel dizzy or weak, you should not drive or operate tools or machines. It's important to let your doctor know about any dizziness as your dose may need adjusting. This side-effect usually affects fewer than 1 in 10 people.
Is it safe to drink alcohol while taking ranolazine?
The article does not specifically mention alcohol. However, it does state that you should not drink grapefruit juice as it increases the amount of ranolazine in your bloodstream, making side-effects more likely. For other drinks, if you have concerns, it's best to consult with your doctor or pharmacist.
How long will I need to take ranolazine?
Treatment with ranolazine is usually long-term unless you experience an adverse effect or are advised otherwise by your doctor. You should continue taking the tablets as prescribed.
Can I stop taking ranolazine once my angina pain improves?
No, you should not stop taking ranolazine unless advised by your doctor, as treatment is usually long-term. Continue taking the tablets as prescribed even if your symptoms improve.
What should I do if I experience an irregular heart rhythm while taking ranolazine?
If you experience an irregular heart rhythm, you should inform your doctor. Before starting ranolazine, it's important to tell your doctor if you already know you have an irregular heart rhythm, as this is a condition where extra care may be needed.
Lecturas adicionales y referencias
- Manufacturer's PIL, Ranexa® 375 mg, 500 mg and 750 mg prolonged-release tablets; A. Menarini Farmaceutica Internazionale SRL, The electronic Medicines Compendium. Dated January 2021.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Siguiente revisión prevista: 16 de enero de 2028
16 Ene 2025 | Última versión

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