Propiltiouracilo comprimidos
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 17 Apr 2025
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Keep your regular appointments with your doctor so that your condition can be monitored and any dose adjustments made. You will need to have regular blood tests.
The most common side-effects include stomach upset, aches and pains, a mild itchy rash, and changes to the way some things taste. These are not usually serious and soon pass.
Propylthiouracil can, however, cause serious liver problems in some people, so if you develop severe or persistent sickness, itching, any yellowing of your skin or the whites of your eyes (jaundice), or tummy pain, or if you generally feel unwell without cause, please contact your doctor for advice straightaway.
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About propylthiouracil
Tipo de medicamento | An antithyroid medicine |
Utilizado para | Hipertiroidismo |
Disponible como | Tabletas |
Propylthiouracil is used to treat an overactive thyroid gland (hyperthyroidism). When the thyroid gland is overactive it makes too much of a hormone called thyroxine. The extra thyroxine causes many of the body's functions to speed up. This can lead to symptoms such as losing weight, excessive sweating, feeling irritable or shaky, and diarrhoea. You also may feel tired or worried, and women may develop menstrual problems.
Although the most commonly used antithyroid medicine in the UK is called carbimazole, some people are unable to take this medicine. If so, propylthiouracil is usually used as a suitable alternative. It works by reducing the amount of thyroxine made by your thyroid gland.
Before taking propylthiouracil
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking propylthiouracil it is important that your doctor knows:
If you are pregnant or breastfeeding (even though propylthiouracil could still be prescribed for you).
Si tiene algún problema con el funcionamiento de su hígado, o si tiene algún problema con el funcionamiento de sus riñones.
Si está tomando otros medicamentos. Esto incluye todos los medicamentos que se pueden comprar sin receta, así como las hierbas medicinales y los medicamentos complementarios.
Si alguna vez ha tenido una reacción alérgica a un medicamento.
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How to take propylthiouracil
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about propylthiouracil, and will also provide you with a full list of the side-effects which you could experience from taking it.
Take the tablets exactly as your doctor tells you to. It is likely that you will be asked to take a high dose to start with, such as 4-8 tablets a day in divided doses. Your dose will then be gradually reduced to 1-3 tablets a day as your thyroid levels become more normal. Your doctor will give you the full directions for taking the tablets, and the information will also be printed on the label of the pack of tablets to remind you about what the doctor said to you.
Swallow your doses with a drink of water. Propylthiouracil tablets can be taken either with or without food.
Try to take your tablets around the same times of day each day. This will help you to remember to take propylthiouracil regularly.
Si olvida tomar una dosis, tómela en cuanto se acuerde (a menos que sea casi la hora de la siguiente dosis, en cuyo caso omita la dosis olvidada). No tome dos dosis juntas para compensar la dosis olvidada.
Aproveche al máximo su tratamiento
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress and any dose adjustments can be made. You will need to have blood tests from time to time to check that you are on the correct dose and that your liver is working well. This is because propylthiouracil can occasionally cause serious liver problems.
Propylthiouracil should have some effect on your symptoms around three to four weeks after treatment starts. Your thyroid hormone levels should be stabilised within four to eight weeks. Continue to take the tablets for as long as you are advised to do so by your doctor.
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Can propylthiouracil cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with propylthiouracil. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common propylthiouracil side-effects | ¿Qué puedo hacer si me ocurre esto? |
Sentirse enfermo (náuseas) o estar enfermo (vómitos), malestar estomacal | Stick to simple foods - avoid rich or spicy food |
Dolor de cabeza, dolores musculares | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores persisten, informe a su médico. |
Changes in taste, feeling tired, mild skin rash and itching | Discuss these with your doctor if they become troublesome |
Important: if you notice any of the following you should contact your doctor straightaway as it could be a sign of a problem with your liver:
Dark urine or light-coloured stools.
Estar enfermo (vómitos)
Pain in your tummy (abdomen).
Any yellowing of your skin or the whites of your eyes (jaundice).
Itchy skin or unexplained bruising.
Pérdida de apetito.
Any unexplained flu-like symptoms.
Feeling unusually tired or generally unwell.
Si experimenta cualquier otro síntoma que crea que puede deberse a los comprimidos, hable con su médico o farmacéutico para que le aconsejen.
How to store propylthiouracil
Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda inmediatamente al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.
Si compra algún medicamento, compruebe con un farmacéutico que es seguro tomarlo con sus otros medicamentos.
Si va a someterse a una operación o a un tratamiento dental, comunique a la persona que lleve a cabo el tratamiento qué medicamentos está tomando.
Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.
No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.
Si tiene cualquier duda sobre este medicamento, pregunte a su farmacéutico.
Informar de los efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.
Lecturas complementarias y referencias
- Manufacturer's PIL, Propylthiouracil 50 mg tablets; RPH Pharmaceuticals AB, The electronic Medicines Compendium. Dated December 2020.
- Medicamentos BNF completa 89ª edición; Asociación Médica Británica y Real Sociedad Farmacéutica de Gran Bretaña, Londres.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
Next review due: 17 Apr 2028
17 Apr 2025 | Latest version

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