Promethazine
Avomine, Phenergan, Sominex
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 18 Mar 2023
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Promethazine is an antihistamine.
You may need to take one or more doses during a day, depending upon the reason you are taking it. Make sure you carefully follow the directions on the label.
Promethazine may affect your ability to drive and to use tools or machines.
The most common side-effects are feeling sleepy, headache, dry mouth and blurred vision.
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About promethazine
Tipo de medicamento | Un antihistamínico |
Usado para | Allergic conditions such as hay fever; to prevent sickness (nausea); and as a sedative |
También llamado | Avomine®, Vertigon® (promethazine teoclate); Phenergan®, Sominex® (promethazine hydrochloride) |
Disponible como | Tabletas, medicina líquida oral e inyección |
Promethazine belongs to a group of medicines known as sedating los antihistamínicos. It has several uses.
It is used to prevent (or treat) feelings of sickness (nausea). It is commonly recommended for sickness associated with travel and for vértigo.
It is also used to relieve allergies such as fiebre del heno y allergic skin rashes.
Promethazine also makes you feel sleepy (has a sedative effect). It may be taken (for a few days only) to help promote sleep in adults with sleeping problems. It has been popular in the past as a means of 'settling' children, but promethazine should not be used in this way.
Promethazine is available on prescription, or you can buy it without a prescription at pharmacies. It is not suitable for children under 2 years of age.
Before taking promethazine
Volver al contenidoTo make sure this is the right treatment for you, before you start taking promethazine it is important that you discuss the treatment with a doctor or pharmacist if:
You are pregnant, trying for a baby or breastfeeding.
You have a problem with the way your liver works, or if you have a problem with your kidneys.
You have a slow or irregular heartbeat.
You have a condition which causes increased pressure in your eyes, such as glaucoma.
You have prostate problems or if you have been experiencing any difficulty passing urine.
Sabes que tienes una obstrucción en tus intestinos delgados.
Tiene epilepsia.
You have any long-term breathing problems, such as asthma or chronic obstructive pulmonary disease (COPD).
You have a low level of potassium in your blood (hypokalaemia).
Está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
You have ever had an allergic reaction to a medicine.
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How to take promethazine
Volver al contenidoBefore you start this treatment, read the manufacturer's printed information leaflet from inside your pack. There are a number of different brands and strengths of promethazine tablet. The manufacturer's leaflet will give you more information about the brand you have been given. It will also contain a full list of the side-effects which you may experience from taking promethazine.
Take promethazine exactly as your doctor or pharmacist has told you to. You may be asked to take one or more doses during a day, depending upon the reason why you are taking it.
If you are taking promethazine to prevent travel sickness, it is usually recommended that you take the first dose at bedtime on the evening before you are due to travel. You can then take a further dose on the morning of your travel if needed.
You can take promethazine before or after meals. Some people find it helps to swallow the tablets with a drink of water.
If you are giving promethazine liquid medicine to a child, make sure you follow the dosing instructions on the bottle carefully so that you measure out the correct dose for the age of your child.
Most people only need to take an antihistamine for a short while when they have symptoms. You should stop taking promethazine once your symptoms have eased. Do not take promethazine for more than a few days for sleeping problems.
Obteniendo el máximo de tu tratamiento
Volver al contenidoPromethazine may cause drowsiness and blurred vision. If this happens to you, do not drive and do not use tools or machines. Alcohol will make the drowsiness worse, so it is best not to drink alcohol while you are on promethazine.
If you are pregnant, only take promethazine on the advice of your doctor. Do not take promethazine in the last two weeks before your baby is born as it could cause side-effects for your baby.
If you are having an operation or any treatment (particularly if it is to test for an allergy), tell the person carrying out the treatment that you are taking promethazine.
Promethazine may cause your skin to become more sensitive to sunlight than normal. Use a sunscreen that protects against UVA light and has a sun protection factor (SPF) of at least 15, especially in strong sunlight or until you know how your skin reacts. Do not use sunbeds.
If you buy any medicines, check with a pharmacist that they are safe to take with an antihistamine. This is because a number of other medicines can interfere with the way promethazine works and can increase the risk of side-effects.
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Can promethazine cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with promethazine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any continue or become troublesome.
Común promethazine side-effects | ¿Qué puedo hacer si experimento esto? |
Sensación de mareo o somnolencia, y visión borrosa | Do not drive and do not use tools or machines. Do not drink alcohol |
Dolor de cabeza | Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, stop taking promethazine or speak with your doctor |
Boca seca | Intenta chupar caramelos sin azúcar o masticar chicle sin azúcar |
Difficulty passing urine | Hable con su médico si esto se vuelve problemático |
Stomach upset, constipation | Try to eat a well-balanced diet and drink plenty of water |
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
How to store promethazine
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Lecturas adicionales y referencias
- Manufacturer's PIL, Phenergan® 10 mg Tablets; Sanofi, The electronic Medicines Compendium. Dated October 2021.
- Manufacturer's PIL, Sominex® 20 mg Tablets; Teva UK Ltd, The electronic Medicines Compendium. Dated May 2022.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 17 Mar 2026
18 Mar 2023 | Última versión

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