Pamidronato disódico
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 19 Jul 2023
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Pamidronate disodium is given by intravenous infusion in a hospital clinic.
You may feel tired or dizzy for up to 24 hours after having the infusion. You should not drive yourself home after your treatment. Do not drive and do not use tools or machines if you are affected
Your doctor may recommend that you see your dentist before you have this treatment
Take care to avoid becoming dehydrated during treatment - ask your doctor how much you should drink.
De un vistazo
Pamidronate disodium is a medicine given by injection to treat certain bone problems.
It can reduce bone pain and high calcium levels in cancer patients.
It also helps make bones stronger for people with Paget's disease of bone.
You will receive this medicine as a slow intravenous infusion in a hospital clinic.
Tell your doctor if you are pregnant, breastfeeding, or have kidney, liver, or heart conditions.
Good dental hygiene is important; inform your dentist about this treatment.
Do not drive or use machines if you feel tired or dizzy after your infusion.
About pamidronate disodium
Tipo de medicamento | Bisfosfonato |
Usado para | To prevent bone pain in people with cancer that has spread to the bone; to reduce high levels of calcium in the blood caused by cancer; Paget's disease of bone |
Disponible como | Inyección |
Pamidronate disodium, a bifosfonato, is prescribed for a number of different problems which affect bones. It can be prescribed to ease bone pain or to reduce hypercalcaemia associated with some cancers. It is also prescribed for people with Enfermedad ósea de Paget to prevent bone damage.
In some cancers there can be an excessive breakdown of bone. As this happens, calcium is lost from the bone and seeps into the blood, leading to higher than normal levels of calcium in the blood. This is called hypercalcaemia. Pamidronate disodium binds to bone and reduces the rate at which it is broken down. This helps strengthen bones by preventing the loss of calcium and this reduces the high levels of calcium in the blood.
In Paget's disease of bone, pamidronate disodium works on bones to make them stronger and help prevent bone thickening. This helps ease symptoms such as pain, bone damage and fracture.
Before having pamidronate disodium
Algunos medicamentos no son adecuados para personas con ciertas condiciones, y a veces un medicamento solo puede usarse si se tiene especial cuidado. Por estas razones, antes de comenzar el tratamiento es importante que su médico sepa:
Si estás embarazada o amamantando.
If you are due to have any dental treatment in the near future, or if you have reportado recently had a dental check-up.
Si tienes una afección cardíaca.
If you have any problems with the way your kidneys work, or the way your liver works.
If you have ever had any surgery on your thyroid gland.
Si le han dicho que tiene bajos niveles de calcio en la sangre.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How you will be given pamidronate disodium
Before you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. It will give you more information about pamidronate disodium and will provide you with a full list of the side-effects which you may experience from having it.
Pamidronate disodium will be given to you in a hospital clinic. It will be made up by the hospital staff and administered by intravenous infusion - this means that it is added into an injection fluid and injected slowly (over an hour or so) into one of your veins.
The number of doses you require will depend upon the reason why it has been prescribed for you. Some people require only a single dose, others require a short course of treatment.
Obteniendo el máximo de tu tratamiento
It is important that you do not become dehydrated during treatment with pamidronate disodium. Your doctor will probably advise you drink a couple of glassfuls of water before and after your treatment.
You may feel tired or dizzy for up to 24 hours after having the infusion. You should not drive yourself home after your treatment. Do not drive and do not use tools or machines if you are affected.
It may be necessary for you to take tablets of calcium and vitamin D as a supplement alongside this treatment. If so, your doctor will prescribe this for you.
Good dental hygiene is important during treatment with this medicine - this means that you must brush your teeth regularly and have regular dental check-ups. Tell your dentist that you are having treatment with pamidronate disodium, as some dental treatments may not be recommended for you.
Remember to follow any lifestyle advice your doctor has given you. Eating a well-balanced diet, stopping smoking and taking regular exercise can help bones stay strong.
Keep your regular appointments with your doctor so your progress can be monitored. You will need to have regular blood tests during this treatment.
Can pamidronate disodium cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with pamidronate disodium. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common pamidronate disodium side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Sintiéndose somnoliento o cansado | Do not drive and do not use tools or machines straight after receiving treatment |
Fever and flu-like symptoms, headache, other aches and pains | Pídale a su médico o farmacéutico que le recomiende un analgésico adecuado, y descanse mucho y beba abundantes líquidos |
Stomach upset (such as feeling sick (nausea), abdominal discomfort, diarrhoea or constipation) | Mantente con alimentos simples y bebe mucha agua para reponer los líquidos perdidos |
Sleeping problems, rash, eye problems (such as conjunctivitis), tingling feelings, feeling flushed | If any become troublesome, speak with your doctor |
Cambios en el ritmo cardíaco y cambios en algunos resultados de análisis de sangre | Su médico supervisará estos |
Less common, but possibly serious side-effects | ¿Qué debo hacer si experimento esto? |
Dolor en el muslo, cadera o ingle | Speak with your doctor - these can be signs of a thighbone fracture |
Un diente flojo, o dolor de mandíbula con hinchazón o entumecimiento | Speak with your doctor - these can be signs of a problem called osteonecrosis of the jaw |
Dolor de oído, secreción del oído, infección de oído | Estos podrían ser signos de un problema llamado osteonecrosis del oído. Hable con su médico de inmediato |
Si experimenta otros síntomas que cree que pueden deberse al medicamento, hable con su médico o farmacéutico para obtener más consejos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Si compras algún medicamento, consulta con un farmacéutico que sea seguro tomarlo junto con tus otros medicamentos.
Si vas a someterte a una operación o a un tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
Siempre lea el prospecto impreso que viene con su medicamento.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What is pamidronate?
Pamidronate disodium is a type of medicine known as a bisphosphonate. It's used to treat various bone-related issues, including preventing bone pain in people with cancer that has spread to the bone, reducing high calcium levels in the blood caused by cancer, and managing Paget's disease of bone.
How does pamidronate disodium help with hypercalcaemia in cancer patients?
In some cancers, bones break down excessively, releasing calcium into the blood, which causes high calcium levels (hypercalcaemia). Pamidronate disodium works by binding to the bone and slowing down this breakdown process. This action helps to strengthen bones by preventing calcium loss and thus reduces the high levels of calcium in the blood.
How does pamidronate disodium treat Paget's disease of bone?
For Paget's disease of bone, pamidronate disodium acts on the bones to make them stronger and prevents them from thickening. This helps to alleviate symptoms such as pain, bone damage, and the risk of fracture associated with the condition.
Will I need to take other medications with pamidronate disodium?
During your treatment with pamidronate disodium, your doctor might also prescribe calcium and vitamin D supplements. This is to ensure your body maintains appropriate levels of these nutrients alongside the pamidronate treatment.
What should I do if I feel dizzy or tired after the infusion?
It is common to feel tired or dizzy for up to 24 hours after receiving the infusion. You should not drive yourself home after your treatment. If you are still affected, it's advised not to drive or operate any tools or machinery.
Are there any specific lifestyle changes I should make while on this treatment?
Your doctor may give you lifestyle advice, which is important to follow. Maintaining a well-balanced diet, stopping smoking, and engaging in regular exercise can all contribute to keeping your bones strong while you are receiving this treatment.
Lecturas adicionales y referencias
- Manufacturer's PIL, Pamidronate Disodium 3 mg/ml, 6 mg/ml and 9 mg/ml Sterile Concentrate; Hospira UK Ltd, The electronic Medicines Compendium. Dated February 2023.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 18 Jul 2026
19 Jul 2023 | Última versión

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