Olanzapine long-acting injection
Zypadhera
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 12 Dic 2022
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Olanzapine long-acting injection will be given to you by your clinic doctor or nurse every 2-4 weeks.
The injection may cause you to feel sleepy or dizzy for a few hours afterwards.
If you miss an appointment for an injection, make another appointment as soon as possible.
There are a number of side-effects which you could experience from the treatment. If you are concerned about any, you should discuss them with your doctor.
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About olanzapine long-acting injection
Tipo de medicamento | An antipsychotic injection |
Usado para | Maintenance of symptom control in adults with schizophrenia and other similar mental health problems |
También llamado | Zypadhera® (olanzapine embonate) |
Disponible como | Long-acting depot injection |
Olanzapine belongs to a group of medicines called antipsicóticos. You will have been prescribed it to maintain symptom control of esquizofrenia.
Schizophrenia is a mental health condition that causes disordered ideas, beliefs and experiences. Symptoms of schizophrenia include hearing, seeing, or sensing things that are not real, having mistaken beliefs, feeling unusually suspicious, and becoming withdrawn. Olanzapine is used to relieve the symptoms of schizophrenia and other similar mental health problems. It works on the balance of chemical substances in your brain.
Long-acting, or 'depot', injections are used once your symptoms have been eased by taking tablets. The injection slowly releases olanzapine into your body and is given either every two weeks, or every four weeks. The main advantage of a depot injection is that you do not have to remember to take tablets every day.
Before having olanzapine long-acting injection
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start having olanzapine long-acting injections, it is important that your doctor knows:
Si estás embarazada o amamantando.
Si tienes una afección cardíaca o enfermedad de los vasos sanguíneos.
Si tienes algún problema con el funcionamiento de tu hígado, o si tienes algún problema con el funcionamiento de tus riñones.
If you have prostate problems.
Si tienes algún problema con tu respiración.
If you have any of the following: epilepsia, diabetes (diabetes mellitus), depresión, enfermedad de Parkinson, raised pressure in your eye (glaucoma) or a condition which causes muscle weakness, called myasthenia gravis.
If you have ever had yellowing of your skin or the whites of your eyes (ictericia).
If you have a blood or bone marrow disorder.
If you are very constipated or think you may have a blockage in your bowel.
Si ha tenido una reacción alérgica a un medicamento.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
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How olanzapine long-acting injection is given
Volver al contenidoBefore you start the treatment, ask to read the manufacturer's printed information leaflet from inside the pack. The leaflet will give you more information about olanzapine, and it will also provide you with a full list of the side-effects which you could experience.
Olanzapine long-acting injection will be given to you in an outpatient clinic by a doctor or nurse. The injection is given into a muscle in your bottom (buttocks). As a routine, you will be asked to stay in the clinic where you can be observed for at least three hours after each injection. This is because it can make you feel tired or dizzy after it is given. You will be advised not to drive and not to use tools or machines for the remainder of the day.
You may be asked to continue taking your current tablets for a short while after you have had your first injection. This is because it can take a few weeks before you feel the full effect from the injection.
Treatment with olanzapine is usually long-term so that your symptoms don't return.
Obteniendo el máximo de tu tratamiento
Volver al contenidoYour treatment will require careful monitoring to make sure that you get the best possible benefit from olanzapine. Keep your regular doctor's appointments so that you get your injections on time, and your progress can be checked. If you miss an appointment for an injection, contact the hospital to arrange for another appointment as soon as possible.
Olanzapine could cause your skin to become more sensitive to sunlight than normal. Avoid strong sunlight and sunbeds, and use a sun cream with a high sun protection factor even on bright but cloudy days.
If you drink alcohol, ask your doctor for advice about drinking while you are on olanzapine. Alcohol can increase the chance that you will experience side-effects and may not be advisable for you.
If you have diabetes you may need to check your blood sugar (glucose) more frequently, as olanzapine can affect the levels of sugar in your blood. Your doctor will advise you about this.
If you are having any dental treatment or an operation, tell the person carrying out the treatment that you have had an olanzapine injection. This is important because it may interfere with the anaesthetic you receive.
If you buy or take any 'over-the-counter' medicines, check with a pharmacist that they are suitable for you to take with olanzapine.
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Can olanzapine long-acting injection cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with olanzapine. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common olanzapine side-effects (these affect more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Feeling sleepy, tired or dizzy | No conduzca ni utilice herramientas o máquinas mientras esté afectado |
Increased weight | Eat a well-balanced diet. Speak with your doctor if your weight becomes troublesome |
Cambios en algunos resultados de análisis de sangre | Su médico supervisará estos |
Common olanzapine side-effects (estos afectan a menos de 1 de cada 10 personas) | ¿Qué puedo hacer si experimento esto? |
Feeling restless | Speak with your doctor about this |
Pain at the site of the injection | This should not last long. If the area becomes red, swollen or 'lumpy', let your doctor know |
Boca seca | Intenta masticar chicle sin azúcar o chupar caramelos sin azúcar |
Estreñimiento | Drink plenty of water, and eat a well-balanced diet containing plenty of fruit, vegetables, and fibre |
Unusual or uncontrollable muscle movements, shakiness | Speak with your doctor about these |
Increased appetite and weight, rash, feeling hot, reduced interest in sex, erectile dysfunction, aches and pains | Consulte a su médico si alguno de estos le causa molestias |
Importante: if you experience symptoms such as muscle stiffness, a very high temperature, feeling confused or sweaty, a fast heartbeat, and urinary incontinence, you should contact your doctor immediately. These can be signs of a rare but serious condition known as neuroleptic malignant syndrome.
If you experience any other symptoms which you think may be due to the injection, speak with your doctor or pharmacist for further advice.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
If you suspect that you have had an overdose of this medicine, go to the accident and emergency department of your local hospital at once.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Lecturas adicionales y referencias
- Manufacturer's PIL, Zypadhera® 210 mg, 300 mg and 405 mg powder and solvent for prolonged-release suspension for injection; Eli Lilly and Company Limited, The electronic Medicines Compendium. Dated January 2021.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 11 Jun 2027
12 Dic 2022 | Última versión
20 Aug 2010 | Publicado originalmente
Escrito por:
Helen Allen, MPharm

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