Noretisterona para menstruaciones dolorosas o abundantes
Primolut N, Utovlan
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 17 Feb 2023
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Norethisterone is a female hormone treatment.
The usual dose is one tablet either two or three times daily. You may be asked to take the tablets regularly each day, or just to take them on certain days of the month.
The most common side-effects are feeling bloated, feeling sick (nausea), and headache. These are generally mild in nature.
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About norethisterone
Tipo de medicamento | Progestogen (female hormone) |
Utilizado para | Painful or heavy periods, particularly when associated with endometriosis |
También llamado | Norethindrone (in US); Primolut N®, Utovlan® |
Disponible como | Tabletas |
Norethisterone is a man-made form of progesterone, a naturally occurring female sex hormone. It is referred to as a progestogen and it has a number of uses. Low doses are used to prevent pregnancy, or as hormone replacement therapy (HRT). Medium-strength tablets (5 mg) such as Primolut N® and Utovlan® are used to treat heavy and painful periods particularly if they are associated with a condition called endometriosis. Higher doses are used in the treatment of some female cancers, such as breast cancer.
This leaflet discusses norethisterone when it is used to treat painful or heavy periods associated with endometriosis. Endometriosis is a condition where tissue which is normally only found inside the womb (uterus), becomes 'trapped' in other parts of the body, often in the pelvic area or lower abdomen. This causes symptoms such as painful and heavy periods. Treatment aims to reduce the pain and amount of blood loss. Norethisterone can also be considered for heavy periods not associated with endometriosis, although other treatment options are more commonly prescribed for this.
There are a number of other medicine leaflets which will give you more information about norethisterone if you are taking it for contraception or as HRT. These are: Progestogen-only contraceptive tablets, Norethisterone contraceptive injection, Combined hormonal contraceptives and Oestrogen and progestogen for HRT.
Before taking norethisterone
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking norethisterone it is important that your doctor knows:
Si está embarazada o en periodo de lactancia.
If you have any problems with the way your liver works, or any kidney problems.
If you have heart or blood vessel problems, or if you have ever had a blood clot in an artery or vein.
If you have any of the following: diabetes, epilepsy, migraines, high blood pressure (hypertension), or asthma.
If you smoke, are overweight or have high cholesterol levels.
If you have ever had cancer.
Si alguna vez has tenido una enfermedad depresiva.
If you have ever had yellowing of your skin or the whites of your eyes (jaundice), severe itching, or a skin condition called pemphigoid gestationis during a pregnancy.
Si padece un raro trastorno sanguíneo hereditario llamado porfiria.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.
Si alguna vez ha tenido una reacción alérgica a un medicamento.
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How to take norethisterone
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about norethisterone and will provide you with a full list of the side-effects which you may experience from taking it.
Take norethisterone exactly as your doctor tells you to. You may be asked to take the tablets regularly each day, or to take them just on certain days of your monthly cycle. This information will be printed on the label of your pack of tablets to remind you, but if you are still unsure, ask your pharmacist for further advice.
It is common to take one tablet three times each day, although your dose may be different to this.
Swallow the tablets with a drink of water. You can take norethisterone tablets either before or after meals.
Try to take your doses at the same times of day, as this will help you to remember to take your doses.
If you do forget to take a dose at your usual time, take it as soon as you remember, unless it is nearly time for your next dose in which case leave out the forgotten dose. Remember to take your next dose when it is due but do not take two doses together to make up for a forgotten dose.
Aproveche al máximo su tratamiento
Procure acudir a las citas periódicas con su médico. Así podrá comprobar su evolución.
You should avoid getting pregnant, as norethisterone can affect a developing baby. Use barrier methods of contraception (such as a condom) if you have sex whilst taking norethisterone. If you need further contraceptive advice, speak with your doctor.
If you have diabetes you may need to check your blood glucose more frequently, as norethisterone can affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
If you are due to have an operation or any medical treatment, tell the person carrying out the treatment that you are taking norethisterone.
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Can norethisterone cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with norethisterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common norethisterone side-effects | ¿Qué puedo hacer si me ocurre esto? |
Shorter periods, no periods, breakthrough bleeding, 'spotting' | Your doctor will discuss this with you before you start treatment |
Sensación de malestar (náuseas) | Stick to simple meals - avoid rich and spicy foods. If you are not already doing so, try taking the tablets after a meal |
Dolor de cabeza | Ask your pharmacist to recommend a suitable painkiller. If the headache is unusually severe or continues, speak with your doctor straightaway |
Bloating, fluid retention | En caso de molestias, hable con su médico |
Less common norethisterone side-effects | ¿Qué puedo hacer si me ocurre esto? |
Feeling dizzy, breast tenderness, changes in weight, feeling tired or difficulty sleeping, feeling depressed, lack of interest in sex, skin reactions | Si alguno de ellos le resulta molesto, hable con su médico |
Important: norethisterone can also have some serious side-effects, although these occur only rarely. If you experience any of the following symptoms, stop taking the tablets and contact your doctor for advice straightaway:
Any feeling of pain or tightness in your chest.
Any disturbances of your vision or hearing.
Any unusually severe headaches.
Any yellowing of your skin or the whites of your eyes (jaundice).
Si experimenta cualquier otro síntoma que crea que puede deberse a los comprimidos, consulte a su médico o farmacéutico.
How to store norethisterone
Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.
Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.
If you buy any medicines 'over the counter', always check with a pharmacist that they are suitable to take with your other medicines.
No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.
Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.
Informar de los efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.
Lecturas complementarias y referencias
- Manufacturer's PIL, Utovlan® tablets; Pfizer Limited, The electronic Medicines Compendium. Dated December 2018.
- Manufacturer's PIL, Primolut N®; Bayer plc, The electronic Medicines Compendium. Dated July 2021.
- Medicamentos BNF completa 89ª edición; Asociación Médica Británica y Real Sociedad Farmacéutica de Gran Bretaña, Londres.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
Fecha prevista para la próxima revisión: 16 feb 2026
17 Feb 2023 | Última versión

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