Noretisterona para períodos dolorosos o abundantes
Primolut N, Utovlan
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 17 Feb 2023
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Norethisterone is a female hormone treatment.
The usual dose is one tablet either two or three times daily. You may be asked to take the tablets regularly each day, or just to take them on certain days of the month.
The most common side-effects are feeling bloated, feeling sick (nausea), and headache. These are generally mild in nature.
De un vistazo
Norethisterone is a progestogen hormone medicine.
It treats painful or heavy periods, especially with endometriosis.
Take tablets exactly as prescribed by your doctor.
Avoid pregnancy and use barrier contraception while taking this medicine.
Check with your doctor if you have diabetes or are having an operation.
Stop taking it and contact your doctor if you have chest pain, vision changes, severe headaches, or jaundice.
About norethisterone
Tipo de medicamento | Progestogen (female hormone) |
Usado para | Painful or heavy periods, particularly when associated with endometriosis |
También llamado | Norethindrone (in US); Primolut N®, Utovlan® |
Disponible como | Comprimidos |
Norethisterone is a man-made form of progesterone, a naturally occurring female sex hormone. It is referred to as a progestogen and it has a number of uses. Low doses are used to prevent pregnancy, or as hormone replacement therapy (HRT). Medium-strength tablets (5 mg) such as Primolut N® and Utovlan® are used to treat heavy and painful periods particularly if they are associated with a condition called endometriosis. Higher doses are used in the treatment of some female cancers, such as breast cancer.
This leaflet discusses norethisterone when it is used to treat painful or heavy periods associated with endometriosis. Endometriosis is a condition where tissue which is normally only found inside the womb (uterus), becomes 'trapped' in other parts of the body, often in the pelvic area or lower abdomen. This causes symptoms such as painful and heavy periods. Treatment aims to reduce the pain and amount of blood loss. Norethisterone can also be considered for heavy periods not associated with endometriosis, although other treatment options are more commonly prescribed for this.
There are a number of other medicine leaflets which will give you more information about norethisterone if you are taking it for contraception or as HRT. These are: Tabletas anticonceptivas solo de progestágeno, Inyección anticonceptiva de noretisterona, Anticonceptivos hormonales combinados y Oestrogen and progestogen for HRT.
Before taking norethisterone
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking norethisterone it is important that your doctor knows:
Si estás embarazada o amamantando.
If you have any problems with the way your liver works, or any kidney problems.
If you have heart or blood vessel problems, or if you have ever had a blood clot in an artery or vein.
If you have any of the following: diabetes, epilepsy, migraines, high blood pressure (hypertension), or asthma.
If you smoke, are overweight or have high cholesterol levels.
If you have ever had cancer.
If you have ever had a depressive illness.
If you have ever had yellowing of your skin or the whites of your eyes (jaundice), severe itching, or a skin condition called pemphigoid gestationis during a pregnancy.
Si tienes un trastorno sanguíneo hereditario raro llamado porfiria.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take norethisterone
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about norethisterone and will provide you with a full list of the side-effects which you may experience from taking it.
Take norethisterone exactly as your doctor tells you to. You may be asked to take the tablets regularly each day, or to take them just on certain days of your monthly cycle. This information will be printed on the label of your pack of tablets to remind you, but if you are still unsure, ask your pharmacist for further advice.
It is common to take one tablet three times each day, although your dose may be different to this.
Swallow the tablets with a drink of water. You can take norethisterone tablets either before or after meals.
Try to take your doses at the same times of day, as this will help you to remember to take your doses.
If you do forget to take a dose at your usual time, take it as soon as you remember, unless it is nearly time for your next dose in which case leave out the forgotten dose. Remember to take your next dose when it is due but do not take two doses together to make up for a forgotten dose.
Obteniendo el máximo de tu tratamiento
Intenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
You should avoid getting pregnant, as norethisterone can affect a developing baby. Use barrier methods of contraception (such as a condom) if you have sex whilst taking norethisterone. If you need further contraceptive advice, speak with your doctor.
If you have diabetes you may need to check your blood glucose more frequently, as norethisterone can affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
If you are due to have an operation or any medical treatment, tell the person carrying out the treatment that you are taking norethisterone.
Can norethisterone cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with norethisterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common norethisterone side-effects | ¿Qué puedo hacer si experimento esto? |
Shorter periods, no periods, breakthrough bleeding, 'spotting' | Your doctor will discuss this with you before you start treatment |
Sentirse mal (náuseas) | Stick to simple meals - avoid rich and spicy foods. If you are not already doing so, try taking the tablets after a meal |
Dolor de cabeza | Ask your pharmacist to recommend a suitable painkiller. If the headache is unusually severe or continues, speak with your doctor straightaway |
Bloating, fluid retention | Si es problemático, hable con su médico |
Less common norethisterone side-effects | ¿Qué puedo hacer si experimento esto? |
Feeling dizzy, breast tenderness, changes in weight, feeling tired or difficulty sleeping, feeling depressed, lack of interest in sex, skin reactions | Si alguno de estos se vuelve problemático, hable con su médico |
Importante: norethisterone can also have some serious side-effects, although these occur only rarely. If you experience any of the following symptoms, stop taking the tablets and contact your doctor for advice straightaway:
Any feeling of pain or tightness in your chest.
Any disturbances of your vision or hearing.
Any unusually severe headaches.
Any yellowing of your skin or the whites of your eyes (jaundice).
If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for advice.
How to store norethisterone
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
If you buy any medicines 'over the counter', always check with a pharmacist that they are suitable to take with your other medicines.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
Can I take norethisterone if I am currently on my period?
The article states that norethisterone is used to treat heavy and painful periods. Your doctor will provide specific instructions on how to take the medication, which may include taking it regularly each day or only on certain days of your monthly cycle. If you are unsure, you should consult your pharmacist for advice.
How long will I need to take norethisterone for heavy periods?
The article does not specify a duration for taking norethisterone. Your doctor will determine the appropriate length of treatment based on your individual condition and progress. It is important to keep your regular appointments so your doctor can monitor your treatment.
What should I do if I experience breakthrough bleeding or spotting while taking norethisterone?
Shorter periods, no periods, breakthrough bleeding, or 'spotting' are listed as common side-effects of norethisterone. Your doctor should discuss these possibilities with you before you start treatment. If this happens and you are concerned, you should speak with your doctor or pharmacist.
Can norethisterone affect my ability to drive or operate machinery?
The article does not explicitly mention whether norethisterone affects the ability to drive or operate machinery. However, some less common side-effects include feeling dizzy or tired. If you experience these side-effects, it would be wise to exercise caution and avoid activities that require full alertness until you know how the medication affects you. For specific advice, you should consult your doctor or pharmacist.
Are there any specific foods or drinks I should avoid while taking norethisterone?
The article does not list any specific foods or drinks to avoid while taking norethisterone. It does mention that if you experience nausea, sticking to simple meals and avoiding rich or spicy foods can help alleviate this side-effect.
Lecturas adicionales y referencias
- Manufacturer's PIL, Utovlan® tablets; Pfizer Limited, The electronic Medicines Compendium. Dated December 2018.
- Manufacturer's PIL, Primolut N®; Bayer plc, The electronic Medicines Compendium. Dated July 2021.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Next review due: 16 Aug 2027
17 Feb 2023 | Última versión

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