Letrozol para el cáncer de mama
Femara
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 17 Feb 2023
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Take one 2.5 mg letrozole tablet every day. Swallow the tablet with a drink of water.
The most common side-effects of treatment are hot flushes, sweating, joint pain, and feeling tired. These can occur in more than 1 in 10 women who take letrozole.
De un vistazo
Letrozole is a hormone treatment for breast cancer in women who have been through menopause.
It works by reducing the amount of oestrogen in the body, which slows cancer cell growth.
Take one tablet daily at the same time each day, with or without food.
Inform your doctor if you have kidney or liver problems, osteoporosis, or are taking other medicines.
Common side effects include hot flushes, headaches, muscle pain, and tiredness.
Regular bone density tests are needed as letrozole can reduce bone strength.
About letrozole
Tipo de medicamento | An aromatase inhibitor hormone antagonist |
Usado para | Breast cancer in women |
También llamado | Femara® |
Disponible como | Comprimidos |
Letrozole is a hormonal cáncer de mama treatment.
Some breast cancers need the hormone oestrogen to grow. In women who have been through the menopause, the main source of oestrogen is through the change of sex hormones, called androgens, into oestrogen. An enzyme called 'aromatase' is needed for this change to occur. Letrozole works by blocking (inhibiting) this enzyme. This reduces the amount of oestrogen in your body, which slows the growth of the cancer cells.
Before taking letrozole
Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking letrozole it is important that your doctor knows:
If you have not yet gone through the menopause, or if there is a possibility you could be pregnant.
Si tienes algún problema con el funcionamiento de tu hígado, o algún problema con el funcionamiento de tus riñones.
If you have a loss of bone density, or 'brittle bones' - a condition known as osteoporosis.
Si alguna vez has tenido una reacción alérgica a un medicamento.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
How to take letrozole
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about letrozole and it will also provide you with a full list of the side-effects which you could experience from taking it.
Take one 2.5 mg tablet of letrozole each day, exactly as your doctor tells you to.
You can take letrozole at whatever time of day you find easiest to remember, but try to take your doses at the same time of day each day. This will help you to remember to take letrozole regularly.
Swallow the tablet with a drink of water. You can take letrozole either with or without food.
If you forget to take a dose at your usual time, take it as soon as you remember. If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal. Do not take two doses on the same day to make up for a missed dose.
Continue to take the tablets regularly each day until your doctor tells you otherwise. You may need to take letrozole for a number of years.
Obteniendo el máximo de tu tratamiento
Try to keep your regular appointments with your doctor and clinic. This is so your doctor can check on your progress. Letrozole lowers the levels of female hormones in your body, which can reduce the strength of your bones. You will need to have bone density tests to check for this before and during your treatment.
If you are due to have an operation or any dental treatment, tell the person carrying out the treatment that you are taking letrozole.
Si compras algún medicamento 'sin receta', consulta con un farmacéutico para asegurarte de que sea seguro tomarlo junto con tus medicamentos recetados.
Can letrozole cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with letrozole. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following become troublesome.
Muy común letrozole side-effects (these affect more than 1 in 10 women) | ¿Qué puedo hacer si experimento esto? |
Hot flushes, increased sweating | Try to keep cool by wearing light, airy clothes |
Dolor de cabeza, muscular o articular | Drink plenty of water and ask a pharmacist to recommend a suitable painkiller. If it continues, let your doctor know |
Sintiéndose cansado, débil o mareado | No conduzca ni utilice herramientas o máquinas mientras esté afectado |
High blood levels of cholesterol | Your doctor will arrange for you to have tests to check for this |
If you experience other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.
How to store letrozole
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
Is letrozole a form of chemotherapy?
No, letrozole is not a chemotherapy drug. It is a hormonal breast cancer treatment classified as an aromatase inhibitor hormone antagonist. It works by reducing oestrogen in the body, whereas chemotherapy typically works by directly killing cancer cells.
How does letrozole affect my body to treat breast cancer?
Letrozole works by blocking an enzyme called 'aromatase'. In women who have gone through menopause, this enzyme is responsible for converting sex hormones (androgens) into oestrogen. Some breast cancers need oestrogen to grow, so by reducing the amount of oestrogen in your body, letrozole slows the growth of these cancer cells.
What should I do if I accidentally take two doses of letrozole instead of one?
The article states to never take more than the prescribed dose. If you suspect you or someone else has taken an overdose, you should go to the accident and emergency department of your local hospital immediately and take the medicine container with you. Do not try to manage it yourself at home.
How long will I need to continue taking letrozole?
You should continue to take letrozole regularly each day until your doctor tells you otherwise. The article mentions that you may need to take it for a number of years.
What should I do if I'm planning to have surgery or dental work while taking letrozole?
If you are scheduled for an operation or any dental treatment, it is important to inform the person carrying out the treatment that you are currently taking letrozole. This allows them to consider your medication in your treatment plan.
Lecturas adicionales y referencias
- Manufacturer's PIL, Femara® 2.5 mg Tablets; Novartis Pharmaceuticals UK Ltd, The electronic Medicines Compendium. Dated April 2021.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Next review due: 16 Aug 2027
17 Feb 2023 | Última versión

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