Mononitrato de isosorbida
Tardisc, Xismox
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 20 Oct 2024
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Isosorbide mononitrate helps to prevent angina chest pain from developing.
It is not suitable to take to treat an angina attack - you should always carry with you a short-acting nitrate, such as trinitrato de glicerilo (GTN), for if you get angina pain.
The most common side-effect is headache. This should pass after a few days.
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Isosorbide mononitrate is a medicine used to prevent angina chest pain and treat heart failure.
It works by relaxing and widening blood vessels to improve blood flow to the heart and reduce strain.
Doses are taken once, two, or three times daily depending on the type and doctor's instructions.
Do not chew or crush modified-release tablets or capsules.
This medicine is not for treating an angina attack; use your prescribed short-acting nitrate for that.
Common side-effects include headache, dizziness, tiredness, fast heartbeat, and flushing.
Avoid alcohol while taking this medicine as it can increase side-effects.
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About isosorbide mononitrate
Tipo de medicamento | A nitrate |
Usado para | Angina prevention; heart failure |
También llamado | Carmil® XL, Chemydur® XL, Elantan® LA, Imdur®, Isib® XL, Ismo®, Isodur® XL, Isotard® XL, Medomon® XL, Modisal® XL, Monomax® SR, Monomil® XL, Monosorb® XL, Nyzamac® SR, Relosorb® XL, Tardisc® XL, Trangina® XL, Xismox® XL, Zemon® XL, |
Disponible como | Tablets, modified-release (longer-acting) tablets, and modified-release (longer-acting) capsules |
Isosorbide mononitrate helps to prevent angina chest pain from developing. Angina pain develops if part of your heart muscle does not get as much blood and oxygen as it needs. It is usually caused by narrowing of your coronary arteries due to a build-up of a fatty substance called atheroma. The narrowing makes it more difficult for blood to flow to your heart muscle.
Isosorbide mononitrate works in two ways. It relaxes blood vessels in your body (causing them to widen) and this reduces the strain on your heart, making it easier for your heart to pump blood around your body. It also relaxes and widens blood vessels in your heart (coronary arteries) which increases the flow of blood to your heart muscle.
Isosorbide mononitrate is also sometimes prescribed alongside other medicines for people with insuficiencia cardíaca. This is a condition where the heart does not beat as efficiently as it should.
Before taking isosorbide mononitrate
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking isosorbide mononitrate it is important that your doctor knows:
Si estás embarazada o amamantando.
Si tienes algún problema con el funcionamiento de tu hígado, o algún problema con el funcionamiento de tus riñones.
If you have low blood pressure.
If you have been told by a doctor you have low levels of iron in your blood (anaemia), or low levels of oxygen in your blood (hypoxaemia).
Si tienes una glándula tiroides hipoactiva.
Si tienes una afección ocular llamada glaucoma.
Si recientemente has tenido una lesión en la cabeza o un ataque al corazón.
Si alguna vez has tenido una reacción alérgica a un medicamento.
If you are taking other medicines, including those available to buy without a prescription, as well as herbal or complementary medicines. It is particularly important that you tell your doctor if you are using any medicines to help treat erectile dysfunction.
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How to take isosorbide mononitrate
Volver al contenidoBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about nitrate medicines, and it will also provide you with a full list of side-effects which you could experience from taking isosorbide mononitrate.
Some brands of isosorbide mononitrate tablets should be taken two or three times a day. Longer-acting tablets and capsules are taken once daily in the morning. Your doctor will tell you which is the right dose for you, and this will also be printed on the label of the pack to remind you about what the doctor said to you. You can take your doses either before or after meals.
Swallow the tablet/capsule whole - do not chew or crush it before you swallow. This is because the tablets/capsules are specially made to release the medicine they contain in a controlled way.
If you forget to take a dose, take it as soon as you remember. If you do not remember until your next dose is nearly due, then leave out the forgotten dose and take your next dose when it is due. Do not take two doses together to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIsosorbide mononitrate tablets and capsules are not suitable to take to treat the pain of an angina attack. Your doctor will prescribe you a short-acting nitrate for you to take if this happens. Glyceryl trinitrate (GTN) is commonly prescribed for this.
Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress
The longer you take isosorbide mononitrate, the more your body can become used to it (called tolerance), and then it can have less of an effect. To avoid this, if you are taking more than one dose a day, your doses may not be prescribed at equal intervals throughout the day. It is important that you follow the instructions your doctor gives to you about when to take your doses.
It is best not to drink alcohol while you are on isosorbide mononitrate. Alcohol will increase the risk of you experiencing side-effects such as feeling dizzy and light-headed.
Si va a someterse a una operación o tratamiento dental, por favor recuerde informar a la persona que realiza el tratamiento qué medicamentos está tomando.
If you buy any medicines, please check with a pharmacist that they are suitable for you to take with isosorbide mononitrate.
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Can isosorbide mononitrate cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with isosorbide mononitrate. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common isosorbide mononitrate side-effects | ¿Qué puedo hacer si experimento esto? |
Dolor de cabeza | Ask your doctor or pharmacist to recommend a suitable painkiller. This side-effect usually disappears after a few days |
Sensación de mareo o cansancio | No conduzca ni utilice herramientas o máquinas mientras esté afectado |
Fast heartbeat; flushing | Si alguno de estos se vuelve problemático, hable con su médico |
Si experimenta cualquier otro síntoma que crea que puede deberse al medicamento, por favor hable con su médico o farmacéutico para obtener más consejos.
How to store isosorbide mononitrate
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What is angina and how does isosorbide mononitrate help?
Angina is chest pain that occurs when your heart muscle doesn't get enough blood and oxygen. This is often due to narrowed coronary arteries caused by a fatty substance called atheroma. Isosorbide mononitrate helps by relaxing and widening blood vessels in your body, which reduces the strain on your heart, and also directly widens the coronary arteries to improve blood flow to the heart muscle.
Can I take isosorbide mononitrate if I have heart failure?
Yes, isosorbide mononitrate is sometimes prescribed alongside other medicines for people with heart failure. Heart failure is a condition where the heart does not pump blood as efficiently as it should.
Can I crush or chew my isosorbide mononitrate tablets or capsules?
No, you should swallow the tablet or capsule whole. Do not chew or crush it. This is because these forms of the medicine are specially designed to release the medication in a controlled way over time.
Can I drink alcohol while taking isosorbide mononitrate?
It is best not to drink alcohol while you are taking isosorbide mononitrate. Alcohol can increase your risk of experiencing side-effects such as feeling dizzy and light-headed.
What should I do if I forget to take a dose of isosorbide mononitrate?
If you forget to take a dose, take it as soon as you remember. However, if your next dose is nearly due, then you should skip the forgotten dose and take your next dose at the usual time. Do not take two doses together to make up for a missed dose.
Will my body get used to isosorbide mononitrate over time?
Yes, your body can become used to isosorbide mononitrate over time, which is called tolerance, and this can make the medicine less effective. To help prevent this, if you are prescribed more than one dose a day, your doctor may instruct you to take your doses at specific intervals to ensure a period without the medicine each day. It is important to follow your doctor's instructions about when to take your doses.
Are there any medicines I should definitely avoid taking with isosorbide mononitrate?
It is particularly important to tell your doctor if you are using any medicines to help treat erectile dysfunction. You should also check with a pharmacist about any other medicines you buy, including herbal or complementary ones, to ensure they are suitable to take with isosorbide mononitrate.
Lecturas adicionales y referencias
- Manufacturer's PIL, Imdur 60 mg tablets; TopRidge Pharma Ltd, The electronic Medicines Compendium. Dated August 2017.
- Manufacturer's PIL, Isosorbide mononitrate 10 mg tablets; Dexcel Pharma Ltd, The electronic Medicines Compendium. Dated December 2017.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 16 de octubre de 2027
20 Oct 2024 | Última versión

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