Glyburide for diabetes
Glynase
Peer reviewed by Sid DajaniLast updated by Michael Stewart, MRPharmSLast updated 27 Feb 2023
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Take glyburide with, or just after, your first main meal of the day (usually breakfast).
Recuerde seguir todos los consejos que le hayan dado sobre su dieta y la práctica de ejercicio.
Common side-effects include stomach upset and low blood sugar (hypoglycemia). Make sure you know how to recognise the symptoms of low blood sugar. These include feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy.
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About glyburide
Tipo de medicamento | Un medicamento antidiabético a base de sulfonilurea |
Utilizado para | Diabetes mellitus de tipo 2 |
También llamado | Glynase®; Glucovance® (glyburide with metformin) |
Disponible como | Tabletas |
La insulina es una hormona que se produce de forma natural en el páncreas. Ayuda a controlar los niveles de azúcar (glucosa) en la sangre. Si el organismo no produce suficiente insulina o no utiliza eficazmente la que produce, se produce la diabetes (diabetes mellitus).
People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like glyburide are given alongside the changes in diet.
Glyburide (also know as glibenclamide) works by increasing the amount of insulin that your pancreas produces. This helps to reduce the amount of sugar in your blood.
Glyburide is also available in combination with another antidiabetic medicine called metformin. This combination reduces the number of tablets you need to take each day.
Before taking glyburide
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking glyburide it is important that your physician knows:
Si está embarazada, esperando un bebé o en período de lactancia.
Si tiene algún problema con el funcionamiento del hígado o de los riñones.
If you have been told you have porphyria or glucose 6-phosphate dehydrogenase (G6PD) deficiency. These are rare inherited disorders.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que pueda adquirirse sin receta, así como medicamentos a base de plantas y complementarios.
Si alguna vez ha tenido una reacción alérgica a un medicamento.
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How to take glyburide tablets
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about glyburide tablets and will provide you with a full list of the side-effects which you may experience from taking them.
Take glyburide exactly as your physician tells you to. The usual starting dose is 5 mg daily. It is prescribed as a single dose to be taken with, or immediately after, breakfast.
Depending on your blood sugar (glucose) levels, your daily dose may need to be increased. Your physician will do this slowly, usually increasing by one 2.5 mg tablet each week. Your blood sugar levels will need to be tested regularly.
If you need higher doses your physician may ask you to take glyburide twice each day. If this happens take each dose with a meal or snack and try to space your doses evenly.
Different manufacturers' products may contain different amounts of glyburide and have different recommended doses. Each time you get a prescription make sure you receive the same strength of tablet as before. Ask the pharmacist for advice if you are unsure.
If you forget to take a dose at the usual time, take it with your next meal. If you do not remember until the following day, skip the missed dose. Do not take two doses on the same day to make up for a forgotten dose.
Aproveche al máximo su tratamiento
It is important that you keep your regular physician's and laboratory appointments. This is so that your progress can be monitored. You will need regular check-ups with an eye clinic and a foot clinic as well as with your physician and diabetes clinic.
Your physician may recommend that you test for sugar (glucose) in your blood regularly to check that your diabetes is being controlled. Your physician will show you how to do this.
If you have been given advice by your physician about changes to your diet, stopping smoking or taking regular exercise, it is important for you to follow the advice you have been given.
Make sure you know what it feels like if your blood sugar drops too low. This is known as hypoglycemia, or a 'hypo'. The first signs of hypoglycemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy. If this happens, eat something containing sugar, such as dextrose tablets, sugary candy or a sugary soda (non-diet). Then follow this up with a snack such as a sandwich or a banana.
Low blood sugar can occur if you miss a meal, if you exercise more than usual, if you are ill, or if you drink alcohol.
Do not drink alcohol, as it can affect the control of your blood sugar. Ask your physician if you need further advice about this.
Si es usted conductor, debe tener especial cuidado, ya que su capacidad de concentración puede verse afectada si su diabetes no está bien controlada. Es posible que le aconsejen que compruebe sus niveles de azúcar en sangre antes de viajar y que lleve un tentempié en los viajes largos.
All US states have special licensing laws for drivers with medical conditions. You may be required to report your diabetes to local agencies. Ask your physician for advice about the laws in your state.
If you get unusually thirsty, pass urine more frequently than normal, or feel very tired, you should let your physician know. These are signs that there is too much sugar in your blood and your treatment may need adjusting.
Check with your physician before taking up any new physical exercise, as this will have an effect on your blood sugar levels and you may need to check your blood levels more regularly.
Si va a someterse a una operación o a un tratamiento dental, debe informar a la persona que vaya a realizar el tratamiento de que padece diabetes y darle una lista de los medicamentos que está tomando.
Si compra algún medicamento, compruebe siempre con un farmacéutico que es adecuado para usted.
Treatment for diabetes is usually lifelong. Continue to take the tablets unless you are advised otherwise by your physician.
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Can glyburide cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with glyburide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your physician or pharmacist if any of the following continue or become troublesome.
Common glyburide side-effects | ¿Qué puedo hacer si me ocurre esto? |
Nausea or vomiting | Coma alimentos sencillos: evite las comidas ricas o picantes. |
Hard stools that are difficult to pass (constipation) | Seguir una dieta equilibrada y beber mucha agua. |
Loose, watery stools (diarrhea) | Beber mucha agua para reponer los líquidos perdidos |
Signs of low blood sugar (hypoglycemia) Sensación de temblor o ansiedad, sudoración, palidez, hambre, palpitaciones, mareo. | Eat something containing sugar such as a sweet cookie or a sugary drink (not diet) and follow this up with a snack such as a sandwich. Tell your physician if you notice these symptoms |
Increase in weight | If this becomes a problem, let your physician know at your next check-up |
Si experimenta cualquier otro síntoma que considere que puede deberse a este medicamento, consulte a su médico o farmacéutico.
How to store glyburide
Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona puede haber tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital local. Llévese el envase, aunque esté vacío.
Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.
No guarde medicamentos caducados o que no desee. Pregunte a su farmacéutico cómo deshacerse de los medicamentos de forma segura en su zona.
Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.
Informar de los efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.
Lecturas complementarias y referencias
- FDA Drug Label, Glynase® PresTab (glyburide) tablets; Pharmacia and Upjohn Company LLC. DailyMed, National Institutes of Health, U.S National Library of Medicine. Dated October 2017.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
Next review due: 26 Feb 2026
27 Feb 2023 | Latest version
1 mar 2017 | Publicado originalmente
Autores:
Michael Stewart, MRPharmS

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