Gliburida para la diabetes
Glynase
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 27 de febrero de 2023
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Take glyburide with, or just after, your first main meal of the day (usually breakfast).
Recuerda seguir cualquier consejo que te hayan dado sobre tu dieta y hacer ejercicio.
Common side-effects include stomach upset and low blood sugar (hypoglycemia). Make sure you know how to recognise the symptoms of low blood sugar. These include feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy.
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About glyburide
Tipo de medicamento | Un medicamento antidiabético sulfonilurea |
Usado para | Diabetes mellitus tipo 2 |
También llamado | Glynase®; Glucovance® (glyburide with metformina) |
Disponible como | Comprimidos |
Insulin is a hormone which is made naturally in your body, in the pancreas. It helps to control the levels of sugar (glucose) in your blood. If your body does not make enough insulin, or if it does not use the insulin it makes effectively, this results in the condition called diabetes (diabetes mellitus).
People with diabetes need treatment to control the amount of sugar in their blood. This is because good control of blood sugar levels reduces the risk of complications later on. Some people can control the sugar in their blood by making changes to the food they eat but, for other people, medicines like glyburide are given alongside the changes in diet.
Glyburide (also know as glibenclamide) works by increasing the amount of insulin that your pancreas produces. This helps to reduce the amount of sugar in your blood.
Glyburide is also available in combination with another antidiabetic medicine called metformina. This combination reduces the number of tablets you need to take each day.
Before taking glyburide
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking glyburide it is important that your physician knows:
Si estás embarazada, intentando tener un bebé o amamantando.
Si tienes algún problema con el funcionamiento de tu hígado, o con el funcionamiento de tus riñones.
Si le han dicho que tiene porfiria o deficiencia de glucosa-6-fosfato deshidrogenasa (G6PD). Estas son enfermedades hereditarias raras.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
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How to take glyburide tablets
Volver al contenidoBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about glyburide tablets and will provide you with a full list of the side-effects which you may experience from taking them.
Take glyburide exactly as your physician tells you to. The usual starting dose is 5 mg daily. It is prescribed as a single dose to be taken with, or immediately after, breakfast.
Depending on your blood sugar (glucose) levels, your daily dose may need to be increased. Your physician will do this slowly, usually increasing by one 2.5 mg tablet each week. Your blood sugar levels will need to be tested regularly.
If you need higher doses your physician may ask you to take glyburide twice each day. If this happens take each dose with a meal or snack and try to space your doses evenly.
Different manufacturers' products may contain different amounts of glyburide and have different recommended doses. Each time you get a prescription make sure you receive the same strength of tablet as before. Ask the pharmacist for advice if you are unsure.
Si olvida tomar una dosis en el horario habitual, tómela con su próxima comida. Si no lo recuerda hasta el día siguiente, omita la dosis olvidada. No tome dos dosis en el mismo día para compensar una dosis olvidada.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIt is important that you keep your regular physician's and laboratory appointments. This is so that your progress can be monitored. You will need regular check-ups with an eye clinic and a foot clinic as well as with your physician and diabetes clinic.
Your physician may recommend that you test for sugar (glucose) in your blood regularly to check that your diabetes is being controlled. Your physician will show you how to do this.
If you have been given advice by your physician about changes to your diet, stopping smoking or taking regular exercise, it is important for you to follow the advice you have been given.
Make sure you know what it feels like if your blood sugar drops too low. This is known as hypoglycemia, or a 'hypo'. The first signs of hypoglycemia are feeling shaky or anxious, sweating, looking pale, feeling hungry, having a feeling that your heart is pounding (palpitations), and feeling dizzy. If this happens, eat something containing sugar, such as dextrose tablets, sugary candy or a sugary soda (non-diet). Then follow this up with a snack such as a sandwich or a banana.
Low blood sugar can occur if you miss a meal, if you exercise more than usual, if you are ill, or if you drink alcohol.
Do not drink alcohol, as it can affect the control of your blood sugar. Ask your physician if you need further advice about this.
Si eres conductor, debes tener especial cuidado, ya que tu capacidad de concentración puede verse afectada si tu diabetes no está bien controlada. Se te puede aconsejar que verifiques tus niveles de azúcar en sangre antes de viajar y que lleves un refrigerio contigo en viajes largos.
All US states have special licensing laws for drivers with medical conditions. You may be required to report your diabetes to local agencies. Ask your physician for advice about the laws in your state.
If you get unusually thirsty, pass urine more frequently than normal, or feel very tired, you should let your physician know. These are signs that there is too much sugar in your blood and your treatment may need adjusting.
Check with your physician before taking up any new physical exercise, as this will have an effect on your blood sugar levels and you may need to check your blood levels more regularly.
Si tienes programada una operación o tratamiento dental, debes informar a la persona que realizará el tratamiento que tienes diabetes y proporcionarle una lista de los medicamentos que estás tomando.
Si compras algún medicamento, siempre consulta con un farmacéutico para asegurarte de que sean adecuados para ti.
Treatment for diabetes is usually lifelong. Continue to take the tablets unless you are advised otherwise by your physician.
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Can glyburide cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with glyburide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your physician or pharmacist if any of the following continue or become troublesome.
Common glyburide side-effects | ¿Qué puedo hacer si experimento esto? |
Náuseas o vómitos | Mantente en alimentos simples - evita comidas ricas o picantes |
Heces duras que son difíciles de evacuar (estreñimiento) | Come una dieta equilibrada y bebe mucha agua |
Loose, watery stools (diarrhea) | Bebe mucha agua para reponer los líquidos perdidos |
Signs of low blood sugar (hypoglycemia) : sentirse tembloroso o ansioso, sudoración, palidez, hambre, sensación de que el corazón late con fuerza (palpitaciones), mareo | Eat something containing sugar such as a sweet cookie or a sugary drink (not diet) and follow this up with a snack such as a sandwich. Tell your physician if you notice these symptoms |
Aumento de peso | If this becomes a problem, let your physician know at your next check-up |
Si experimenta otros síntomas que cree que pueden deberse a este medicamento, hable con su médico o farmacéutico.
How to store glyburide
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda a la sala de emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No conserve medicamentos caducados o no deseados. Pregunte a su farmacéutico sobre las formas de desechar los medicamentos de manera segura en su área local.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Lecturas adicionales y referencias
- FDA Drug Label, Glynase® PresTab (glyburide) tablets; Pharmacia and Upjohn Company LLC. DailyMed, National Institutes of Health, U.S National Library of Medicine. Dated October 2017.
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Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Siguiente revisión prevista: 26 de agosto de 2027
27 de febrero de 2023 | Última versión
1 Mar 2017 | Publicado originalmente
Escrito por:
Michael Stewart, MRPharmS

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