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Ethinylestradiol for menopausal symptoms or menstrual disorders

Clinical author's note Michael Stewart 18/8/2020: Ethinlyestradiol tablets were discontinued in the UK in July 2020. At the time of review there are no branded or generic products in the UK solely containing ethinylestradiol. It is still available in combination products for oral contraception. Ethinylestradiol may still be available in other countries. This medicine leaflet is based on medical information available in the UK at the time of writing and is left here for reference purposes. Please also refer to the manufacturer's information supplied with your medicine.

For information about ethinylestradiol in contraception please see our separate leaflet called Combined hormonal contraceptives.

Ethinylestradiol is taken in cycles. Make sure you know which days of the month to take a tablet, and which are tablet-free days. If you are uncertain, check with your doctor or pharmacist.

Do not rely on the tablets to prevent pregnancy - they are not intended to be used as a contraceptive.

Your doctor will discuss the benefits and risks of the treatment with you before you begin.

De un vistazo

  • Ethinylestradiol is a man-made oestrogen prescribed for menstrual problems and menopausal symptoms.

  • It is usually taken alongside a progestogen hormone.

  • It helps relieve hot flushes, night sweats, vaginal dryness, and can protect against bone thinning.

  • You typically take one dose daily, with 7-10 tablet-free days a month.

  • Taking this medicine carries some risks, which your doctor will discuss with you.

  • Seek medical advice immediately for sudden chest pain, breathlessness, leg swelling or a severe headache.

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About ethinylestradiol

Tipo de medicamento

An oestrogen (may also be spelled estrogen)

Usado para

Hormone replacement therapy (HRT); menstrual problems

Disponible como

Tablets (discontinued)

Ethinylestradiol is a man-made form of the naturally occurring female hormone called oestrogen. It is prescribed to treat period (menstrual) problems, and also to help ease los síntomas de la menopausia. It is usually prescribed alongside another female hormone called a progestogen.

Ethinylestradiol is used to supplement or replace the body's natural oestrogen. It helps to relieve many of the problems associated with the menopause, such as hot flushes, night sweats and vaginal dryness. It can also help to protect against 'thinning' of the bones (osteoporosis) although other treatments are usually preferred for this.

This leaflet is appropriate if you have been prescribed ethinylestradiol for a menstrual disorder or for hormone replacement therapy (HRT). If you have been prescribed it for any other reason, please ask your doctor for further advice or refer to the manufacturer's printed information leaflet. Ethinylestradiol is also one of the hormones that are used in the contraceptive pill (the pill) - there is more information about this in a separate leaflet called Combined hormonal contraceptives.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking ethinylestradiol it is important that your doctor knows:

  • If you have any unexplained vaginal bleeding, or if you have ever had a problem with your womb such as fibroids, endometriosis, or endometrial hyperplasia (thickening of the lining of your womb).

  • If you have a heart condition or have had a stroke.

  • If you or a close family member have ever had a problem with a blood clot in a vein or artery.

  • If you have had breast cancer or any lumps in your breast, or if a close family member has had breast cancer.

  • If you have any of the following: diabetes (diabetes mellitus), gallstones, migraine, inflammatory bowel disease, systemic lupus erythematosis (SLE), or porphyria.

  • Si tienes un problema con el funcionamiento de tu hígado.

  • Si alguna vez has tenido depresión.

  • If you have been told you have high levels of prolactin in your blood (hyperprolactinaemia).

  • If you or a close relative have ever had high levels of lipids in blood (hypertriglyceridaemia).

  • If you had any problems with jaundice, severe itchy blistering, or any involuntary muscle movements during a pregnancy.

  • If you could be pregnant or if you are breastfeeding.

  • Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.

  • Si alguna vez has tenido una reacción alérgica a un medicamento.

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  • Before you start this treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about ethinylestradiol and will provide you with a full list of the side-effects which you may experience from taking the tablets.

  • It is usual to take one dose of ethinylestradiol a day, although your doctor will ask you to take the tablets on certain days of the month only. It is usual to have 7-10 tablet-free days a month. It is important that you take ethinylestradiol exactly as your doctor tells you to. The directions will be printed on the label of the pack of tablets to remind you, but if there is anything you are still unsure about, ask your pharmacist if you need further advice.

  • Try to take the tablets at the same time of day as this will help you to remember to take your doses regularly. The tablets are easily swallowed with a drink of water.

  • Si olvida tomar una dosis, tómela tan pronto como lo recuerde. Si no lo recuerda hasta el día siguiente, omita la dosis olvidada. No tome dos dosis al mismo tiempo para compensar una dosis perdida.

  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Also, regularly check your breasts for any lumps and remember to attend for any regular breast screening and cervical smear tests.

  • There are some risks which are associated with taking an oestrogen - your doctor will discuss the benefits and risks of the treatment with you before you start. The risks are reduced when small doses are used for short periods of time. If used for a long time the incidence of breast cancer and other adverse effects may increase. Because of this, the decision to continue the treatment needs to be made individually and your progress should be reviewed regularly. If you have any concerns at any time, make an appointment to discuss them with your doctor.

  • Travelling that involves long periods of immobility (more than three hours) can increase the risk of serious side-effects and in rare cases may lead to blood clots. Taking appropriate exercise during the journey and possibly wearing elastic hosiery can reduce this risk. If you would like more advice about this, speak with your doctor or pharmacist.

  • If you are due to have an operation, tell the person carrying out the surgery that you are taking an oestrogen, as you may be advised to stop the treatment for a while if you are likely to be on bed rest.

  • Do not rely on these tablets to prevent pregnancy - they are not intended to be used as a contraceptive. Your doctor will advise you about whether or not you need to use contraception. If at any time you suspect that you may be pregnant, stop taking ethinylestradiol and consult your doctor as soon as possible.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with ethinylestradiol. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Ethinylestradiol side-effects

¿Qué puedo hacer si experimento esto?

Sentirse mal (náuseas)

Eat simple meals (avoid rich or spicy foods).

Dolor de cabeza

Ask your pharmacist to recommend a suitable painkiller. If the headache continues or is unusually severe, speak to your doctor as soon as possible.

Ojos secos

If you wear contact lenses, ask your optician for advice if this becomes troublesome.

Stomach cramps, bloating, weight changes, breast tenderness, fluid retention, rash, changes in sexual desire, mood changes, leg cramps, high blood pressure, kidney stones, menstrual bleeding or spotting

Speak with your doctor if any of these become troublesome.

Stop taking the tablets and contact your doctor for advice de inmediato if you develop any of the following symptoms:

  • Sudden chest pain.

  • Sudden breathlessness (or if you cough up blood).

  • Swelling or pain in a leg.

  • An unusually severe headache.

  • Ictericia.

Si experimenta cualquier otro síntoma que crea que puede deberse a este medicamento, consúltelo con su médico o farmacéutico.

  • Mantenga todos los medicamentos fuera del alcance y la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

Información importante sobre todos los medicamentos

Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.

Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.

Si compras algún medicamento, consulta con un farmacéutico que sean adecuados para tomar con tus otros medicamentos.

Si vas a someterte a una operación o a un tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.

No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.

Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.

Informar efectos secundarios de un medicamento o vacuna

Si experimenta efectos secundarios, puede reportarlos en línea a través de Sitio web de Yellow Card.

verificador de síntomas

¿Inseguro sobre mezclar medicamentos?

Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.

Preguntas frecuentes

Can ethinylestradiol be used for preventing pregnancy?

No, ethinylestradiol tablets are not intended to be used as a contraceptive. You should not rely on them to prevent pregnancy. Your doctor will advise you if you need to use separate contraception.

¿Qué debo hacer si olvido tomar una dosis?

If you forget a dose, take it as soon as you remember. However, if you don't remember until the next day, you should skip the forgotten dose. Do not take two doses at the same time to make up for a missed dose.

Are there any specific checks I need to have while taking ethinylestradiol?

Yes, it's important to keep your regular appointments with your doctor so they can monitor your progress. You should also regularly check your breasts for any lumps and attend any scheduled breast screening and cervical smear tests.

What activities should I be careful with while taking this medicine?

If you are planning to travel for long periods without moving (more than three hours), this can increase your risk of serious side-effects like blood clots. Taking exercise during your journey and possibly wearing elastic hosiery can help reduce this risk. Also, if you are having surgery, tell the surgeon you are taking ethinylestradiol, as you might need to stop the treatment temporarily if you'll be on bed rest.

How long can I expect to take ethinylestradiol?

The decision to continue treatment with ethinylestradiol needs individual consideration, and your progress should be reviewed regularly by your doctor. The risks are reduced when small doses are used for short periods. If used for a long time, the incidence of breast cancer and other adverse effects may increase.

What serious symptoms should make me contact my doctor immediately?

You should stop taking the tablets and contact your doctor straight away if you experience sudden chest pain, sudden breathlessness, coughing up blood, swelling or pain in a leg, an unusually severe headache, or jaundice.

Lecturas adicionales y referencias

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Sobre el autorVer biografía completa

Imagen del autor

Michael Stewart, MRPharmS

Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico

BPharm (Hons), MRPharmS

Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.

Acerca del revisor

Imagen del autor

Sid Dajani

Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.

Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • Next review due: 13 Aug 2026
  • 14 Ago 2023 | Última versión

    Última actualización por

    Michael Stewart, MRPharmS

    Revisado por pares por

    Sid Dajani
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