Eplerenone tablets
Inspra
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 24 Feb 2023
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Take eplerenone tablets once a day.
Do not use salt substitutes while you are taking eplerenone.
Make sure your doctor knows about any other medicines you are taking alongside eplerenone.
At a glance
Eplerenone is a medicine for heart failure, affecting the left side of your heart.
It helps prevent heart failure from worsening by blocking a substance called aldosterone.
Swallow one tablet daily, with or without food, around the same time each day.
Your doctor will do blood tests to check potassium levels, which can be affected.
Common side-effects include dizziness, headache, nausea, diarrhoea, and constipation.
Tell your doctor if you have kidney or liver problems, or high blood potassium before starting.
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About eplerenone
Tipo de medicamento | An aldosterone antagonist |
Usado para | Insuficiencia cardíaca |
También llamado | Inspra® |
Disponible como | Comprimidos |
Insuficiencia cardíaca means that your heart is not functioning as well as it should. In a healthy heart, a set amount of blood enters the heart during each heartbeat and is pumped out again. If you have heart failure, your heart cannot cope with pumping the full amount of blood in each heartbeat.
If you have heart failure which affects the left ventricle of your heart (left-sided heart failure), it can cause you to be short of breath. It can also be associated with a cough. This is generally worse when you are active (for example, walking uphill) or when you are lying flat in bed.
Eplerenone is prescribed alongside other medicines to help prevent worsening of heart failure in people who have left-sided heart failure. It works by blocking the action of a substance in your body called aldosterone. High levels of aldosterone can cause changes that result in heart failure. By blocking aldosterone, eplerenone helps prevent heart failure from worsening.
Before taking eplerenone
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking eplerenone it is important that your doctor knows:
If you have any problems with the way your kidneys work, or if you have any problems with the way your liver works.
If you have been told you have high levels of potassium in your blood.
Si estás embarazada, intentando tener un bebé o amamantando.
Si está tomando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
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How to take eplerenone
Volver al contenidoBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about eplerenone, and it will also provide you with a full list of the side-effects which you could experience from taking it.
Take eplerenone exactly as your doctor tells you to. You will be prescribed one tablet to take every day. There are two strengths of tablet - you will be prescribed the lower-strength (25 mg) tablet to begin with, but this will be increased to the 50 mg strength tablet within a few weeks.
Swallow the tablet whole with a drink of water. You can take eplerenone either with or without food.
Unless your doctor tells you otherwise, you can generally take eplerenone at a time of day you find easy to remember. It is best, however, to try to take the tablets at the same time of day each day, as this will help you to remember to take your doses regularly.
If you forget to take a dose, take one as soon as you remember, if this is during the same day as your dose was due. If you do not remember until the following day, leave out the forgotten dose from the previous day and take the dose that is due as normal. Do not take two doses at the same time to make up for a missed dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoTry to keep your regular appointments with your doctor. This is so your doctor can check on your progress. The salt balance in your bloodstream may be upset by eplerenone and your doctor will want you to have a blood test from time to time to check the amount of potassium in your blood.
Try to avoid things with a high potassium content, such as 'salt substitutes'. This is so the level of potassium in your body does not become too high.
For most people with heart failure, regular exercise is advised. The healthier the heart, the better it will pump. The level of exercise recommended varies from person to person, so before you start to exercise, get the go-ahead from your doctor.
Your doctor may advise you to make some lifestyle changes, like losing weight if you are overweight, reducing the amount of alcohol you drink, and stopping smoking. Following this advice will help to improve the health of your heart.
If you buy any medicines 'over the counter', check with a pharmacist that they are suitable to take with your prescribed medicines. This is because some painkillers called non-steroidal anti-inflammatory drugs (NSAIDs) may not be recommended for you.
Si está programado para una operación o tratamiento dental, informe a la persona que realiza el tratamiento qué medicamentos está tomando.
Treatment with eplerenone is usually long-term, so continue to take the tablets regularly until you are advised otherwise by your doctor.
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Can eplerenone cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the more common ones associated with eplerenone. The best place to find a full list of the side-effects which can be associated with your medicine, is from the manufacturer's printed information leaflet supplied with the medicine. Alternatively, you can find an example of a manufacturer's information leaflet in the reference section below. Speak with your doctor or pharmacist if any of the following continue or become troublesome.
Común eplerenone side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Sensación de mareo o aturdimiento | If you begin to feel dizzy, lie down so that you do not faint, then sit for a few moments before standing. Do not drive and do not use tools or machines while affected. If this continues, speak with your doctor |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, consulta a tu médico |
Sentirse mal (náuseas) | Stick to simple foods - avoid fatty or spicy meals. If this continues, speak with your doctor |
Diarrea | Bebe mucha agua para reponer los líquidos perdidos. Si esto continúa, consulta a tu médico |
Estreñimiento | Come una dieta equilibrada y bebe varios vasos de agua cada día |
Cough, itchy skin rash, kidney problems, muscle spasms, sleeping problems, back pain | Si es problemático, hable con su médico |
Changes to blood tests (such as high blood potassium and high blood cholesterol) | Su médico verificará esto |
Si experimenta cualquier otro síntoma que crea que puede deberse a las tabletas, hable con su médico o farmacéutico para obtener más consejos.
How to store eplerenone
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What exactly is left-sided heart failure and how does eplerenone help it?
Heart failure means your heart isn't pumping blood as effectively as it should. If it affects the left side of your heart (left-sided heart failure), it can lead to shortness of breath and a cough, especially when active or lying flat. Eplerenone works by blocking a substance called aldosterone. High levels of aldosterone can make heart failure worse, so by blocking it, eplerenone helps prevent further deterioration of your condition.
Are there any specific foods or supplements I should avoid while taking eplerenone?
Yes, you should try to avoid things with a high potassium content, such as 'salt substitutes'. This is important to prevent the level of potassium in your body from becoming too high while you are taking eplerenone.
How often will I need blood tests when taking eplerenone?
Your doctor will want you to have blood tests from time to time to check the amount of potassium in your blood. This is because eplerenone can affect the salt balance in your bloodstream.
What should I do if I feel dizzy after taking eplerenone?
If you start to feel dizzy or light-headed, you should lie down to prevent fainting. After a few moments, you can sit up before standing. It's important not to drive or operate tools or machines while you're feeling dizzy. If this problem continues, you should speak with your doctor.
Can I take over-the-counter painkillers like ibuprofen with eplerenone?
If you buy any medicines without a prescription, you should check with a pharmacist to ensure they are suitable to take with eplerenone. Some painkillers, specifically non-steroidal anti-inflammatory drugs (NSAIDs), may not be recommended for you.
How long will I need to take eplerenone?
Treatment with eplerenone is usually long-term. You should continue to take the tablets regularly until your doctor advises you otherwise.
Lecturas adicionales y referencias
- Manufacturer's PIL, Inspra® 25 mg and 50 mg film-coated tablets; Upjohn UK Ltd, The electronic Medicines Compendium. Dated February 2021.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 23 de agosto de 2027
24 Feb 2023 | Última versión

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