Bupropion tablets for help stopping smoking
Zyban
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 9 Nov 2023
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A combination of bupropion with counselling can increase your chance of successfully stopping smoking.
Start taking the tablets at least a week before your target stop date.
The most common side-effect is difficulty sleeping - the risk of this is less if you avoid taking doses near bedtime.
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About bupropion
Tipo de medicamento | A smoking cessation aid |
Utilizado para | Helping people to stop smoking |
También llamado | Zyban® |
Disponible como | Tabletas |
Nicotine is a drug that is inhaled from the tobacco in cigarettes. It gets into the bloodstream, and stimulates the brain. Most regular smokers are addicted to nicotine. Even though you want to quit smoking, it can be difficult to succeed, because nicotine addiction is strong and hard to break. This is where bupropion can help.
Stopping smoking in somebody who smokes regularly causes a reduction of some chemicals in the brain. This leads to withdrawal symptoms such as cravings, anxiety, irritability and other symptoms associated with 'giving up'. Bupropion alters the levels of some of these chemicals and this is possibly how it relieves the withdrawal symptoms.
Bupropion does not 'make' you stop smoking. You still need determination to succeed and to break the smoking habit. A combination of bupropion with counselling from a nurse, doctor, pharmacist, or other health professional increases your chance of successfully stopping smoking. Therefore, most doctors will only prescribe bupropion to people who really want to stop smoking as part of a 'stopping smoking' programme.
Bupropion is also available as a combination product to support weight loss. If you are taking bupropion for this purpose and you need additional information, ask your pharmacist or doctor for advice.
Before taking bupropion
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking bupropion it is important that your doctor knows:
If you are under 18 years of age, or over 65 years old.
Si está embarazada o en periodo de lactancia.
Si tiene algún problema con el funcionamiento del hígado o de los riñones.
Si padece diabetes (diabetes mellitus).
If for any reason you are at risk of having a seizure.
If you have ever had an eating disorder, such as anorexia nervosa or bulimia.
If you have bipolar disorder.
Si padece una enfermedad inflamatoria denominada lupus eritematoso sistémico (también llamado lupus o LES).
If you regularly drink a lot of alcohol or if you have a drug problem.
If you have been told you have a tumour of the brain or spinal cord, or if you have ever had a serious head injury.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. This is particularly important if you are taking digoxin for a heart condition. Your dose of digoxin may need to be adjusted before or after treatment with bupropion.
Si alguna vez ha tenido una reacción alérgica a un medicamento.
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How to take bupropion
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about bupropion and stopping smoking. It will also provide you with a full list of the side-effects which can be associated with bupropion.
Take bupropion exactly as your doctor tells you to. You will be asked to set yourself a date on which to stop smoking. Your doctor will then ask you to start taking bupropion tablets at least a week before this 'quit' date. The aim is to build up the dose so that your body gets used to the medicine before your quit date.
Start by taking one tablet (150 mg) each day for the first six days. Then from day seven onwards, take one tablet twice a day (unless you are told otherwise by your doctor). Make sure that you leave at least eight hours between the doses. Ideally, take one tablet in the morning and one early evening. Remember to stop smoking on the day you have set as your quit date.
It is not important whether you take bupropion tablets before or after food, but it is best if you try to take your doses at the same time(s) each day. This will help you to remember to take the tablets regularly.
Swallow the tablets whole with a glass of water - do not chew or break the tablets before you swallow.
If you forget to take a dose, leave out the missed dose but make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for the forgotten dose.
Aproveche al máximo su tratamiento
Try to keep your regular appointments with your doctor or nurse. This is so that you can be given counselling and encouragement, and also so that a check can be kept on your progress. You will also need to have your blood pressure measured regularly, as this can increase in some people.
Make sure that your doctor or healthcare professional knows if you are taking any other medicines. This is because stopping smoking can change the way your body breaks down certain medicines. So, as a result of quitting, the dose of some prescribed medicines may need to be adjusted.
A full course of treatment with bupropion will last for 7-9 weeks in total. If you are still smoking after seven weeks, let your doctor know about this so that you can discuss the options that are available to you.
After your course of treatment, your doctor may suggest that you gradually reduce the dose over a few days before you finally stop taking the tablets.
Si compra algún medicamento, compruebe siempre con un farmacéutico que es seguro tomarlo con sus otros medicamentos.
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Can bupropion cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with bupropion. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Some of the symptoms may also occur as a result of stopping smoking.
Common bupropion side-effects | ¿Qué puedo hacer si me ocurre esto? |
Dificultad para dormir | Try to avoid taking your last dose near to bedtime |
Feeling dizzy, difficulty concentrating | Si esto ocurre, no conduzca ni utilice herramientas o máquinas hasta que se sienta mejor. |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza persisten, informe a su médico. |
Boca seca | Prueba a mascar chicle sin azúcar o chupar caramelos sin azúcar |
Sentirse enfermo (náuseas) o estar enfermo (vómitos), malestar estomacal | Keep to simple foods. Try taking the tablets after meals |
Estreñimiento | Seguir una dieta equilibrada y beber mucha agua al día. |
Mood changes, changes to the way things taste, feeling shaky, itchy rash, sweating, high temperature (fever) | En caso de molestias, hable con su médico |
Important: if you feel depressed or start having thoughts about harming yourself, you must let your doctor know straightaway. Depression can occur as a symptom of nicotine withdrawal and it can also on occasion occur as a result of taking bupropion.
On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Seek medical attention if you develop any combination of the following:
Rigidez muscular o movimientos bruscos.
Latidos del corazón inusualmente rápidos.
Temperatura alta (fiebre), sensación de malestar (náuseas) o estar enfermo (vómitos), diarrea.
Delirios o visiones (alucinaciones).
Si experimenta cualquier otro síntoma que crea que puede deberse a los comprimidos, hable con su médico o farmacéutico para que le aconsejen.
How to store bupropion
Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.
This medicine is for you. Do not give it to others, even if their condition appears to be the same as yours.
If you are having any medical treatment, tell the person carrying out the treatment which medicines you are taking.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about your medicines, ask your pharmacist.
MHRA - Notificación de reacciones adversas
Notifique a la Agencia Reguladora de Medicamentos y Productos Sanitarios las sospechas de efectos secundarios de medicamentos, vacunas, cigarrillos electrónicos, incidentes con productos sanitarios o productos defectuosos o falsificados para garantizar un uso seguro y eficaz.
Lecturas complementarias y referencias
- Manufacturer's PIL, Zyban® 150 mg prolonged-release film-coated tablets; GlaxoSmithKline UK, The electronic Medicines Compendium, August 2023.
- Medicamentos BNF completa 89ª edición; Asociación Médica Británica y Real Sociedad Farmacéutica de Gran Bretaña, Londres.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
Fecha prevista para la próxima revisión: 8 nov 2026
9 Nov 2023 | Última versión

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