Bupropion tablets for help stopping smoking
Zyban
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 9 Nov 2023
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A combination of bupropion with counselling can increase your chance of successfully stopping smoking.
Start taking the tablets at least a week before your target stop date.
The most common side-effect is difficulty sleeping - the risk of this is less if you avoid taking doses near bedtime.
De un vistazo
Bupropion (Zyban®) is a medicine used to help people stop smoking.
It can help to ease withdrawal symptoms by altering brain chemicals.
Bupropion works best when combined with counselling as part of a stop smoking programme.
Take tablets exactly as prescribed, starting a week before your quit date.
Do not chew or break tablets; swallow them whole with water.
If you feel depressed or have thoughts of harming yourself, tell your doctor straightaway.
About bupropion
Tipo de medicamento | A smoking cessation aid |
Usado para | Helping people to stop smoking |
También llamado | Zyban® |
Disponible como | Comprimidos |
Nicotine is a drug that is inhaled from the tobacco in cigarettes. It gets into the bloodstream, and stimulates the brain. Most regular smokers are addicted to nicotine. Even though you want to quit smoking, it can be difficult to succeed, because nicotine addiction is strong and hard to break. This is where bupropion can help.
Stopping smoking in somebody who smokes regularly causes a reduction of some chemicals in the brain. This leads to withdrawal symptoms such as cravings, anxiety, irritability and other symptoms associated with 'giving up'. Bupropion alters the levels of some of these chemicals and this is possibly how it relieves the withdrawal symptoms.
Bupropion does not 'make' you stop smoking. You still need determination to succeed and to break the smoking habit. A combination of bupropion with counselling from a nurse, doctor, pharmacist, or other health professional increases your chance of successfully stopping smoking. Therefore, most doctors will only prescribe bupropion to people who really want to stop smoking as part of a 'stopping smoking' programme.
Bupropion is also available as a combination product to support weight loss. If you are taking bupropion for this purpose and you need additional information, ask your pharmacist or doctor for advice.
Before taking bupropion
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking bupropion it is important that your doctor knows:
If you are under 18 years of age, or over 65 years old.
Si estás embarazada o amamantando.
Si tienes algún problema con el funcionamiento de tu hígado, o algún problema con el funcionamiento de tus riñones.
Si tienes diabetes (diabetes mellitus).
If for any reason you are at risk of having a seizure.
If you have ever had an eating disorder, such as anorexia nervosa or bulimia.
If you have bipolar disorder.
Si tienes una condición inflamatoria llamada lupus eritematoso sistémico (también conocido como lupus o LES).
If you regularly drink a lot of alcohol or if you have a drug problem.
If you have been told you have a tumour of the brain or spinal cord, or if you have ever had a serious head injury.
If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. This is particularly important if you are taking digoxin for a heart condition. Your dose of digoxin may need to be adjusted before or after treatment with bupropion.
Si alguna vez has tenido una reacción alérgica a un medicamento.
How to take bupropion
Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about bupropion and stopping smoking. It will also provide you with a full list of the side-effects which can be associated with bupropion.
Take bupropion exactly as your doctor tells you to. You will be asked to set yourself a date on which to stop smoking. Your doctor will then ask you to start taking bupropion tablets at least a week before this 'quit' date. The aim is to build up the dose so that your body gets used to the medicine before your quit date.
Start by taking one tablet (150 mg) each day for the first six days. Then from day seven onwards, take one tablet twice a day (unless you are told otherwise by your doctor). Make sure that you leave at least eight hours between the doses. Ideally, take one tablet in the morning and one early evening. Remember to stop smoking on the day you have set as your quit date.
It is not important whether you take bupropion tablets before or after food, but it is best if you try to take your doses at the same time(s) each day. This will help you to remember to take the tablets regularly.
Swallow the tablets whole with a glass of water - do not chew or break the tablets before you swallow.
If you forget to take a dose, leave out the missed dose but make sure that you remember to take your next dose when it is due. Do not take two doses together to make up for the forgotten dose.
Obteniendo el máximo de tu tratamiento
Try to keep your regular appointments with your doctor or nurse. This is so that you can be given counselling and encouragement, and also so that a check can be kept on your progress. You will also need to have your blood pressure measured regularly, as this can increase in some people.
Make sure that your doctor or healthcare professional knows if you are taking any other medicines. This is because stopping smoking can change the way your body breaks down certain medicines. So, as a result of quitting, the dose of some prescribed medicines may need to be adjusted.
A full course of treatment with bupropion will last for 7-9 weeks in total. If you are still smoking after seven weeks, let your doctor know about this so that you can discuss the options that are available to you.
After your course of treatment, your doctor may suggest that you gradually reduce the dose over a few days before you finally stop taking the tablets.
Si compras algún medicamento, siempre consulta con un farmacéutico que sea seguro tomarlos junto con tus otros medicamentos.
Can bupropion cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with bupropion. You will find a full list in the manufacturer's information leaflet supplied with your medicine. Some of the symptoms may also occur as a result of stopping smoking.
Common bupropion side-effects | ¿Qué puedo hacer si experimento esto? |
Difficulty sleeping | Try to avoid taking your last dose near to bedtime |
Feeling dizzy, difficulty concentrating | Si esto ocurre, no conduzca y no use herramientas o máquinas hasta que se sienta mejor |
Dolor de cabeza | Bebe mucha agua y pide a tu farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza continúan, informa a tu médico |
Boca seca | Intenta masticar chicle sin azúcar o chupar caramelos sin azúcar |
Sentirse mal (náuseas) o vomitar (vómitos), malestar estomacal | Keep to simple foods. Try taking the tablets after meals |
Estreñimiento | Come una dieta equilibrada y bebe mucha agua cada día |
Mood changes, changes to the way things taste, feeling shaky, itchy rash, sweating, high temperature (fever) | Si es problemático, hable con su médico |
Importante: if you feel depressed or start having thoughts about harming yourself, you must let your doctor know de inmediato. Depression can occur as a symptom of nicotine withdrawal and it can also on occasion occur as a result of taking bupropion.
On rare occasions, medicines that affect the level of serotonin in the brain can cause it to go too high and cause problems. The risk is higher if you are taking more than one medicine with this effect. Seek medical attention if you develop any combination of the following:
Músculos rígidos o movimientos 'bruscos'.
Latidos del corazón inusualmente rápidos.
High temperature (fever), feeling sick (nausea) or being sick (vomiting), diarrhoea.
Sentirse delirante o ver visiones (alucinar).
Si experimenta cualquier otro síntoma que crea que puede deberse a las tabletas, hable con su médico o farmacéutico para obtener más consejos.
How to store bupropion
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
This medicine is for you. Do not give it to others, even if their condition appears to be the same as yours.
If you are having any medical treatment, tell the person carrying out the treatment which medicines you are taking.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
If you have any questions about your medicines, ask your pharmacist.
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Informe los efectos secundarios sospechosos de medicamentos, vacunas, cigarrillos electrónicos, incidentes con dispositivos médicos, productos defectuosos o falsificados (falsos) a la Agencia Reguladora de Medicamentos y Productos Sanitarios para garantizar un uso seguro y efectivo.

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Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
Can I stop smoking without additional support if I'm taking bupropion?
Bupropion helps with the physical withdrawal symptoms, but it does not make you stop smoking on its own. You still need determination to break the habit. Combining bupropion with counselling from a health professional significantly increases your chances of success. Most doctors will only prescribe bupropion as part of a structured 'stopping smoking' programme.
What if I miss a scheduled dose of bupropion?
If you forget to take a dose, you should skip the missed dose. Do not take two doses together to try and catch up. Simply take your next scheduled dose when it is due.
Should I be concerned about my blood pressure while taking bupropion?
Yes, your blood pressure needs to be checked regularly while you are taking bupropion. In some people, blood pressure can increase as a side effect.
What should I do if I've been taking bupropion for seven weeks and I am still smoking?
If you are still smoking after seven weeks of treatment, you should inform your doctor. They will then discuss the available options with you.
Will bupropion interact with other medicines I'm taking, especially non-prescription ones?
Yes, it's very important to tell your doctor about all medicines you are taking, including those bought without a prescription, and any herbal or complementary medicines. For instance, if you are taking digoxin for a heart condition, its dose may need adjustment. Also, when you quit smoking, your body's way of processing certain medicines can change, so other prescribed medicine doses might need adjusting.
How long will I be taking bupropion for in total?
A full course of treatment with bupropion typically lasts for 7-9 weeks. After this period, your doctor might suggest gradually reducing your dose over a few days before you completely stop taking the tablets.
Lecturas adicionales y referencias
- Manufacturer's PIL, Zyban® 150 mg prolonged-release film-coated tablets; GlaxoSmithKline UK, The electronic Medicines Compendium, August 2023.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
Sobre el autorVer biografía completa

Michael Stewart, MRPharmS
Gerente de Revisión de Folletos de Medicamentos – Contratista, Farmacéutico
BPharm (Hons), MRPharmS
Michael es un farmacéutico comunitario que ejerce en Midlands y South Yorkshire con más de 20 años de experiencia asesorando sobre medicamentos y condiciones médicas. Tiene una sólida formación en capacitación en atención médica, habiendo producido e impartido cursos de formación para equipos de farmacia y personal de entornos de atención residencial, incluidas enfermeras. También ha contribuido a juntas asesoras de farmacia para la gestión de condiciones de baja gravedad en la comunidad.
Acerca del revisor

Sid Dajani
Sultan Dajani se graduó en la Escuela de Farmacia de Londres en 1994 y se convirtió en el miembro más joven elegido para el consejo de la Sociedad Real de Farmacia desde su fundación en 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Artículo también disponible en Inglés, Alemán, Español, Francés, Italiano, Portugués, Hindi, Hebreo, Árabe, y Sueco.
Próxima revisión: 8 de noviembre de 2026
9 Nov 2023 | Última versión

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