Brimonidine eye drops for glaucoma
Alphagan
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 26 Nov 2024
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Brimonidine eye drops are used to control increased pressure within your eye (glaucoma).
Remember to use the drops regularly, twice a day.
If you normally wear soft contact lenses, please make sure your doctor knows about this.
At a glance
Brimonidine eye drops are used to lower high pressure inside your eye.
They help to prevent optic nerve damage in people with glaucoma and ocular hypertension.
Use one drop in the affected eye(s) twice a day, 12 hours apart.
Common side-effects include dry eye, blurred vision, eye redness, and stinging.
Do not wear soft contact lenses unless your doctor advises it.
If eye drops make your vision blurry, wait until it clears before driving or using machines.
Once opened, eye drop bottles should be discarded after four weeks.
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Video picks for Medicina para el cuidado de los ojos
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About brimonidine eye drops
Tipo de medicamento | An alpha2-adrenoceptor agonist eye drop |
Usado para | To reduce raised eye pressure |
También llamado | Alphagan® |
Disponible como | Gotas para los ojos |
An increase in pressure within your eye can lead to damage to the optic nerve at the back of your eye. When this occurs it is called glaucoma. Glaucoma can lead to a loss of vision if it is not treated. If you have an increased pressure within your eye but without any damage to the optic nerve, this is called ocular hypertension. People with ocular hypertension have an increased risk of later developing glaucoma. Treatment with brimonidine eye drops helps to reduce eye pressure in people with ocular hypertension, and to prevent further eye damage in people with glaucoma.
Brimonidine eye drops are thought to work by reducing the amount of fluid that you make in the front part of your eye (called aqueous humour) and by increasing the drainage of fluid from your eye. These two actions help to lower the pressure within your eye.
Sometimes, more than one type of eye drop is needed to keep the pressure in the eye low. If this is the case for you, you may be asked to use two different eye drops, or you may be given drops which combine more than one type. Brimonidine is available as a combination eye drop with timolol (a beta-blocker) in a brand called Combigan®, and with brinzolamide (a carbonic anhydrase inhibitor) in a brand called Simbrinza®.
Before using brimonidine eye drops
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start using the eye drops, it is important that your doctor knows:
Si usas lentes de contacto blandos.
Si estás embarazada o amamantando.
If you have a heart condition or blood vessel disorder.
If you have a blood circulation problem (particularly if you have Raynaud's syndrome).
If you feel dizzy when you sit up or stand up quickly.
If you have a depressive illness.
Si tienes algún problema con el funcionamiento de tu hígado, o algún problema con el funcionamiento de tus riñones.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
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How to use brimonidine eye drops
Volver al contenidoWash your hands well before you use the drops.
Retire la tapa.
Inclina un poco la cabeza hacia atrás y tira del párpado inferior hacia abajo para formar un bolsillo.
Sostén la botella boca abajo cerca de tu ojo. Intenta no tocar tu ojo mientras haces esto.
Apply enough pressure to the bottle to release one drop into your eye. (Do not use more than one drop - using several drops does not improve your glaucoma but will increase the risk of side-effects.)
Close your eye for a minute or two and press gently on the side of your nose where the corner of your eye meets your nose. This helps to stop the drop from draining away and keeps it in your eye.
Repite el proceso en tu otro ojo si te han indicado usar las gotas en ambos ojos.
Coloca de nuevo la tapa.
Obteniendo el máximo de tu tratamiento
Volver al contenidoBefore you start using the eye drops, read the manufacturer's printed information leaflet from the pack. It will give you more information about the eye drops and will provide you with a full list of the side-effects which you may experience from using them.
Use one drop into the eye (or eyes) affected. The drops are used twice each day, 12 hours apart. Your dose will also be printed on the label of the bottle to remind you.
Remember to use the drops at regular intervals and try not to miss any doses. If you do forget, use them as soon as you remember (unless it is nearly time for your next dose, in which case just use the drops when they are next due). Do not 'double up' to make up for a missed dose.
Take care not to touch the tip of the dropper with your eye, fingers, or any other surface. This is to prevent the drops from becoming contaminated.
If you are using any other eye drops, leave 5-10 minutes between applying each one. This is to prevent more liquid going into your eye than it can handle. Otherwise the drops will overflow from your eye and not have the intended effect.
When first put in, eye drops can make your eyes water and may sometimes cause blurred vision. If this happens, it should quickly clear. Make sure you can see clearly again before you drive, or use tools or machines.
Do not wear soft contact lenses unless your doctor has advised you otherwise. This is because bottles of eye drops contain preservatives which can affect soft contact lenses.
Keep your regular appointments with your doctor and eye clinic so that your progress can be checked.
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Can brimonidine eye drops cause problems?
Volver al contenidoAlong with their useful effects, eye drops can cause unwanted side-effects although not everyone experiences them. The table below contains the most common ones associated with brimonidine. You will find a full list in the manufacturer's information leaflet supplied with the drops. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist for further advice if any of the following continue or become troublesome.
Side-effects of brimonidine eye drops (some of these can be very common affecting more than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Dry eye, blurred vision, eye redness, stinging and irritation, sensitivity to light | These symptoms should soon pass, but make sure you can see clearly before driving or before using tools or machines. If this continues or becomes troublesome, speak with your doctor |
Sintiéndose cansado, somnoliento o mareado | If this happens, do not drive and do not use tools or machines until the feeling passes |
Dolor de cabeza | Ask your pharmacist to recommend a suitable painkiller. If the headache continues, speak with your doctor |
Boca seca | Try chewing sugar-free gum, or sucking sugar-free sweets |
Cold-like symptoms, stomach upset, unusual taste | Si alguno de estos se vuelve problemático, hable con su médico |
Importante: occasionally people can be allergic to eye drops, particularly if the eye drops contain a preservative. If you notice a rash around your eyes, or any swelling or itching, stop using the drops and contact a doctor or pharmacist for advice. Long-term use of preserved eye drops may lead to eye irritation and symptoms of dry eyes. If your eyes or eyelids become red or inflamed after using the drops, contact your doctor for advice.
How to store brimonidine eye drops
Volver al contenidoEye drops can be used for four weeks once the bottle has been opened. Even if there is still some solution remaining after this time, throw it away and use a new bottle. This will help to prevent the risk of eye infections.
Mantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Si compra algún medicamento, consulte con un farmacéutico que sean seguros para tomar con sus medicamentos recetados.
This preparation is for use in the eyes only. If someone swallows some of it, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás tomando.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
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Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
What happens if I forget to use my brimonidine eye drops?
If you forget to use your eye drops, use them as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Do not use extra drops to compensate for a forgotten dose.
How long should I wait between applying brimonidine eye drops and other eye drops?
If you are using other eye drops in addition to brimonidine, you should leave a gap of 5-10 minutes between applying each type of drop. This ensures that your eye can absorb each medicine properly and prevents any overflow.
Why might my vision be blurry right after using the eye drops?
When you first apply eye drops, it is common for your eyes to water or for your vision to become temporarily blurred. This should clear up quickly. It's important to make sure your vision is clear again before you drive or operate any tools or machinery.
Can I wear my soft contact lenses while using brimonidine eye drops?
Generally, it's not advised to wear soft contact lenses when using these eye drops unless your doctor has specifically told you otherwise. This is because the preservatives in the eye drops can affect soft contact lenses.
What should I do if I experience irritation or redness around my eyes after using brimonidine eye drops?
If you notice a rash, swelling, itching around your eyes, or if your eyes or eyelids become red or inflamed after using the drops, you should stop using them and contact your doctor or pharmacist for advice. This could indicate an allergic reaction, or it might be related to the preservatives in the drops.
How long can I use a bottle of brimonidine eye drops once it's been opened?
Once you've opened a bottle of brimonidine eye drops, you should use it for no longer than four weeks. After this period, even if there's still some liquid left, you should dispose of it and start a new bottle. This helps to prevent the risk of eye infections.
Lecturas adicionales y referencias
- Manufacturer's PIL, Alphagan® 0.2% w/v (2 mg/ml) eye drops, solution; AbbVie Ltd, The electronic Medicines Compendium. Dated June 2024.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Next review due: 26 Nov 2027
26 Nov 2024 | Última versión

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