Aprepitant para prevenir la enfermedad
Emend
Revisado por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSÚltima actualización 28 dic 2022
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Aprepitant is an anti-sickness medicine. It is taken alongside other medicines to help stop sickness (nausea and vomiting) after chemotherapy.
Take one 125 mg capsule an hour before chemotherapy, and then one 80 mg capsule each morning for the following two days.
The most common side-effects are hiccups, indigestion, constipation and headache.
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About aprepitant
Tipo de medicamento | Neurokinin-receptor antagonist anti-sickness medicine |
Utilizado para | Prevention of sickness (nausea and vomiting) associated with chemotherapy |
También llamado | Emend® |
Disponible como | Capsules, oral powder sachets |
Aprepitant is known as a neurokinin-receptor antagonist. It is prescribed alongside other medicines (dexamethasone and 5HT3-receptor antagonists such as ondansetron) to help stop you from feeling or being sick after chemotherapy. It works by blocking the effect of a naturally produced chemical, called 'substance P'.
Before taking aprepitant
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking aprepitant it is important that your doctor knows:
Si está embarazada o en periodo de lactancia.
Si tiene algún problema con el funcionamiento de su hígado.
Si alguna vez ha tenido una reacción alérgica a un medicamento.
If you have a rare, inherited blood disorder called porphyria.
If you are taking any other medicines, including any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines. Aprepitant interferes with a number of other medicines, including the 'pill' and the 'mini pill'.
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How to take aprepitant
Before you start treatment, read the manufacturer's printed information leaflet from inside your pack. The manufacturer's leaflet will give you more information about aprepitant and a full list of side-effects which you may experience from taking it.
Take aprepitant capsules exactly as your doctor tells you to. You will be asked to take one 125 mg capsule one hour before your chemo treatment starts, and then one 80 mg capsule each morning for the following two days.
Swallow the capsules whole - it may help to take your doses with a drink of water. It is not important whether you take the capsules before or after food.
If your child has been prescribed oral powder sachets, the dose will be prepared and given to your child by a doctor or nurse in hospital.
If you forget to take a dose, contact your doctor for advice about what to do. Do not take two doses together to make up for a missed one.
Aproveche al máximo su tratamiento
Even if you do not feel like eating or drinking, try to sip water regularly to prevent you from becoming lacking in fluid in the body (dehydrated).
Rather than trying to eat three main meals a day, try eating small, simple but nourishing snacks, every few hours.
If you are using hormonal contraception (this includes the 'pill' and the 'mini pill'), additional contraceptive precautions such as a condom will be required while you are on aprepitant, and for two months afterwards. If you need further advice about this, speak with your doctor or pharmacist.
If you buy any medicines, check with a pharmacist that they are suitable to take with your other medicines. This is because many other medicines can interfere with aprepitant and therefore may not be recommended for you.
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Can aprepitant cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with aprepitant. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common aprepitant side-effects - these affect fewer than 1 in 10 people who take this medicine | ¿Qué puedo hacer si me ocurre esto? |
Dolor de cabeza | Bebe mucha agua y pide a un farmacéutico que te recomiende un analgésico adecuado. Si los dolores de cabeza persisten, informe a su médico. |
Feeling tired, sleepy or dizzy | Do not drive and do not use tools or machines if affected |
Estreñimiento | Try to eat a well-balanced diet, and drink several glasses of water each day |
Loss of appetite, hiccups, indigestion | En caso de molestias, hable con su médico |
Cambios en algunos análisis de sangre | Su médico lo comprobará |
Si experimenta cualquier otro síntoma que considere que puede deberse a este medicamento, consulte a su médico o farmacéutico.
How to store aprepitant
Mantenga todos los medicamentos fuera del alcance y de la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Información importante sobre todos los medicamentos
No tome nunca más de la dosis prescrita. Si sospecha que usted u otra persona ha tomado una sobredosis de este medicamento, acuda al servicio de urgencias de su hospital. Llévese el envase, aunque esté vacío.
Este medicamento es para usted. Nunca se lo dé a otras personas aunque su enfermedad parezca ser la misma que la suya.
Si va a someterse a una operación o a un tratamiento dental, comunique a la persona que lleve a cabo el tratamiento qué medicamentos está tomando.
No guarde medicamentos caducados o que no desee. Llévelos a su farmacia local, que se encargará de eliminarlos por usted.
Si tiene cualquier duda sobre este medicamento pregunte a su farmacéutico.
Informar de los efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede notificarlos en línea a través del sitio web de la Tarjeta Amarilla.
Lecturas complementarias y referencias
- Manufacturer's PIL, Emend® 80 mg, 125 mg hard Capsules; Merck Sharp & Dohme Limited, The electronic Medicines Compendium. Dated September 2022.
- Medicamentos BNF completa 89ª edición; Asociación Médica Británica y Real Sociedad Farmacéutica de Gran Bretaña, Londres.
Historia del artículo
La información de esta página ha sido redactada y revisada por médicos cualificados.
Fecha límite de la próxima revisión: 27 dic 2025
28 dic 2022 | Última versión
22 Oct 2013 | Publicado originalmente
Autores:
Helen Allen, Farmacéutica

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