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Antazoline and xylometazoline eye drops

Otrivine-Antistin

Otrivine-Antistin® drops relieve eye itching and redness associated with allergies.

Use one drop two or three times a day in both eyes. Do not use the drops for more than seven days.

When first put in, eye drops can cause blurred vision. Wait until this clears before you drive.

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About antazoline and xylometazoline eye drops

Tipo de medicamento

Anti-allergy eye drops

Usado para

To relieve the eye symptoms of allergies such as hay fever

También llamado

Otrivine-Antistin®

Disponible como

Gotas para los ojos

The drops contain two ingredients. Antazoline is an antihistamine; it helps relieve allergic itchiness by blocking the release of a chemical called histamine, which is produced by the body as part of an allergic reaction. Xylometazoline is a sympathomimetic agent; it works on the blood vessels in the eye to reduce redness. Antazoline and xylometazoline eye drops (brand name Otrivine-Antistin®) are used to treat conjuntivitis alérgica.

Allergic conjunctivitis causes red, watery and itchy eyes. It is caused by exposure to irritants such as plant pollens, pet fur, cosmetics or house dust mite. Seasonal allergic conjunctivitis occurs at certain times in a year, a common cause being an allergy to pollen in the fiebre del heno season. Perennial allergic conjunctivitis persists throughout the year. This is commonly due to an allergy to house dust mite or animal hair. Antazoline and xylometazoline eye drops are available on prescription, or you can buy them without a prescription at a pharmacy. They can be used by adults and by children over 12 years of age.

To make sure this is the right treatment for you, before you start using the eye drops it is important that your doctor or pharmacist knows:

  • Si usas lentes de contacto blandos.

  • If you have any of the following: high blood pressure, an overactive thyroid gland, diabetes, increased pressure in your eye (glaucoma), heart or blood vessel disease, difficulty passing urine, or a tumour on your adrenal glands, called phaeochromocytoma.

  • Si estás embarazada o amamantando. Esto se debe a que, mientras esperas o alimentas a un bebé, solo debes usar medicamentos bajo la recomendación de un médico.

  • If you have ever had an allergic reaction to an antihistamine or to any eye drops.

  • Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.

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  1. Wash your hands well before you use the drops.

  2. Retire la tapa.

  3. Tilt your head back a little and pull the lower lid of your eye out to form a pocket.

  4. Sostén la botella boca abajo cerca de tu ojo. Intenta no tocar tu ojo mientras haces esto.

  5. Gently squeeze the bottle to release one drop into your eye. Only use a second drop if the first drop missed going into your eye.

  6. Cierra el ojo durante uno o dos minutos y presiona suavemente el lado de tu nariz donde la esquina de tu ojo se encuentra con tu nariz. Esto ayuda a evitar que la gota se drene y la mantiene en tu ojo.

  7. Repeat the process in your other eye.

  8. Coloca de nuevo la tapa.

  • Before you start using the eye drops, read the manufacturer's printed information leaflet from the pack. It will give you more information about the drops and will provide you with a full list of the side-effects which you may experience from using them.

  • Use the eye drops two or three times a day in both eyes, unless you have been told otherwise by your doctor.

  • Take care not to touch your eye, fingers, or any other surface with the dropper of the bottle. This could infect the liquid left in the bottle.

  • When you first put the drops into your eye, it may cause blurred vision. This should quickly clear, but make sure you can see clearly again before you drive and before using machines or tools.

  • If you are using any other eye drops, leave 5-10 minutes between using the other eye drops. This is to prevent more liquid going into your eye than it can handle. Otherwise the drops will overflow from your eye and not have the intended effect.

  • Do not wear soft contact lenses while you are using the eye drops unless your doctor has advised you otherwise. This is because lenses will irritate your eyes, and also because there is a preservative in the drops which can affect soft contact lenses.

  • If your symptoms do not improve within a few days, or if they become worse, make an appointment to see a doctor.

  • Your doctor will tell you how long to use the drops for. You should notice an improvement in your symptoms within a few days, but treatment for up to seven days is sometimes required. Do not use the drops for more than seven consecutive days.

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Along with their useful effects, eye drops can cause unwanted side-effects although not everyone experiences them. The table below contains the most common one associated with antazoline and xylometazoline eye drops. You will find a full list in the manufacturer's information leaflet supplied with your drops. Unwanted effects often improve as your body adjusts to a new medicine, but speak with your doctor or pharmacist if the following continues or becomes troublesome.

Antazoline and xylometazoline eye drop side-effects


¿Qué puedo hacer si experimento esto?

Mild eye discomfort (such as burning or stinging)

This usually disappears within a few minutes of using the drops. Do not drive and do not use tools or machines unless your vision is clear

Occasionally people can be allergic to eye drops, particularly when the eye drops contain a preservative. If you notice a rash around your eyes, or any swelling or increased itching, stop using the drops and contact a doctor for advice. If you experience any other symptoms which you think may be due to the eye drops, speak with your doctor or pharmacist for further advice.

  • Mantenga todos los medicamentos fuera del alcance y la vista de los niños.

  • Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.

  • Eye drops only keep for four weeks once the bottle has been opened so throw away the bottle after you have finished the course of treatment, even if there is some solution left. Never keep opened bottles of eye drops to use later. This helps to prevent the risk of eye infections.

Información importante sobre todos los medicamentos

If you buy any medicines check with a pharmacist that they are safe to use with your other medicines.

Never use more than the recommended dose.

If you suspect that someone has swallowed some of this medicine by accident, contact the accident and emergency department of your local hospital for advice.

Si vas a someterte a una operación o tratamiento dental, informa a la persona que realiza el tratamiento sobre los medicamentos que estás usando.

Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.

No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.

Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.

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Lecturas adicionales y referencias

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Historial del artículo

La información en esta página está escrita y revisada por pares por clínicos calificados.

  • Próxima revisión: 31 Mar 2027
  • 6 de mayo de 2024 | Última versión

    Última actualización por

    Michael Stewart, MRPharmS

    Revisado por pares por

    Sid Dajani
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