Amlodipine tablets
Istin, Norvasc
Revisado por pares por Sid DajaniÚltima actualización por Michael Stewart, MRPharmSLast updated 4 Jul 2023
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Amlodipine is taken once a day.
You can take the tablets before or after meals.
When you first start taking amlodipine you may get a headache, or feel flushed and hot. These symptoms tend to go after the first few days.
At a glance
Amlodipine is a medicine taken once a day for high blood pressure or to prevent angina.
It works by relaxing and widening blood vessels, which lowers blood pressure and reduces heart strain.
Common side-effects can include headache, flushing, dizziness, and swollen ankles.
Do not drink large quantities of grapefruit juice, as it might increase amlodipine effects.
If you forget a dose, take it when you remember, unless it's the next day; do not take two doses.
Do not stop taking amlodipine suddenly, as symptoms may return.
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About amlodipine
Tipo de medicamento | Calcium-channel blocker |
Usado para | High blood pressure; angina |
También llamado (Reino Unido) | Istin® |
También llamado (EE.UU.) | Norvasc® |
Disponible como | Tablets, oral liquid medicine, capsules (USA) |
Amlodipine is given to treat presión arterial alta (hipertensión). It is also taken to help prevent dolor de pecho por angina. You may have been prescribed it for either of these reasons.
Amlodipine works by causing some of your blood vessels to relax and widen. This lowers your blood pressure. It also reduces the force and the rate of your heartbeat, and this helps to prevent angina chest pain. It does these things by blocking the amount of calcium that goes into the 'smooth' muscle cells in the walls of your arteries and in your heart. Calcium is needed for muscles to contract, so reducing the amount of calcium causes the muscle cells to relax.
Amlodipine is also available as a combination tablet with other medicines to reduce high blood pressure. Combination tablets help to reduce the total number of tablets you need to take each day.
Before taking amlodipine
Volver al contenidoSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking amlodipine it is important that your doctor knows:
Si estás embarazada o amamantando.
Si tienes problemas con el funcionamiento de tu hígado.
Si está tomando o usando otros medicamentos. Esto incluye cualquier medicamento que esté tomando y que esté disponible para comprar sin receta, así como medicamentos herbales y complementarios.
Si alguna vez has tenido una reacción alérgica a un medicamento.
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How to take amlodipine
Volver al contenidoBefore you start this treatment, read the manufacturer's printed information leaflet from inside your pack. It will give you more information about amlodipine and will provide you with a full list of the side-effects which you may experience from taking the tablets.
Amlodipine is taken once a day. It is usual to be prescribed the 5 mg strength tablet to take at first, although the strength of your tablets may be increased to 10 mg after a short while.
You can generally choose a time of day to take your tablets that you find easiest to remember, but try to take your doses at the same time of day each day. This will help you to avoid missing doses.
Swallow the tablet with a drink of water. You can take amlodipine before or after meals.
If you forget to take a dose at your usual time, take it as soon as you remember. If you do not remember until the following day, leave out the missed dose. Do not take two doses together to make up for a forgotten dose.
Obteniendo el máximo de tu tratamiento
Volver al contenidoIntenta mantener tus citas regulares con tu médico. Esto es para que tu médico pueda verificar tu progreso.
Your doctor will discuss with you the possibility of unwanted side-effects. When you first start taking amlodipine you may experience headaches, feeling flushed, and some dizziness. These effects usually only last for a few days, but if they continue or become troublesome, you should let your doctor know.
If you drink alcohol, ask your doctor for advice. Your doctor may recommend that you do not drink alcohol while you are on this medicine, as it may increase the chance that you experience side-effects, such as feeling dizzy or light-headed.
Treatment with amlodipine is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are told otherwise by your doctor. If it is necessary for you to stop, your doctor may want you to reduce your dose over a few days, as suddenly stopping taking amlodipine can cause your symptoms to return.
If you buy any medicines, always check with a pharmacist that they are suitable to take with your other medicines. Some anti-inflammatory painkillers may reduce the effectiveness of amlodipine.
If you need to have an operation or any medical treatment, always tell the person carrying out the treatment which medicines you are taking. Amlodipine may interfere with the way some anaesthetics work.
It is not advisable for you to drink large quantities of grapefruit juice. This is because a chemical in grapefruit juice may increase the amount of amlodipine in your bloodstream and this could make side-effects more likely.
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Can amlodipine cause problems?
Volver al contenidoAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with amlodipine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Común amlodipine side-effects (these affect fewer than 1 in 10 people) | ¿Qué puedo hacer si experimento esto? |
Headache, feeling flushed or hot | These may occur during the first few days but usually soon go. Speak with your doctor if they continue beyond a few days |
Abdominal discomfort, feeling sick (nausea) | Stick to simple meals - avoid rich and spicy foods |
Tobillos hinchados | Raise your legs on to a low stool when you are sitting. Speak with your doctor or a pharmacist if the swelling continues |
Sensación de mareo o cansancio | Si esto ocurre, no conduzca y no use herramientas o máquinas hasta que se sienta mejor |
The sensation of having a 'thumping' heart (palpitations) | Si es problemático, hable con su médico |
Si experimenta cualquier otro síntoma que crea que puede deberse a las tabletas, hable con su médico o farmacéutico para obtener más consejos.
How to store amlodipine
Volver al contenidoMantenga todos los medicamentos fuera del alcance y la vista de los niños.
Almacenar en un lugar fresco y seco, lejos del calor y la luz directos.
Información importante sobre todos los medicamentos
Volver al contenidoInformación importante sobre todos los medicamentos
Nunca tome más de la dosis prescrita. Si sospecha que usted u otra persona podría haber tomado una sobredosis de este medicamento, acuda al departamento de accidentes y emergencias de su hospital local. Lleve el envase con usted, incluso si está vacío.
Este medicamento es para ti. Nunca lo des a otras personas, incluso si su condición parece ser la misma que la tuya.
No guardes medicamentos caducados o no deseados. Llévalos a tu farmacia local, que se encargará de desecharlos por ti.
Si tienes alguna pregunta sobre este medicamento, consulta a tu farmacéutico.
Informar efectos secundarios de un medicamento o vacuna
Si experimenta efectos secundarios, puede reportarlos en línea a través de Yellow Card website.

¿Inseguro sobre mezclar medicamentos?
Verifica posibles interacciones entre medicamentos, suplementos y alimentos antes de tomarlos juntos.
Preguntas frecuentes
How does amlodipine actually help with high blood pressure and angina?
Amlodipine works by relaxing and widening some of your blood vessels, which in turn lowers your blood pressure. For angina, it reduces the force and rate of your heartbeat. It achieves this by blocking calcium from entering 'smooth' muscle cells in your arteries and heart, as calcium is necessary for these muscles to contract.
Can I take amlodipine if I am taking other medications, including over-the-counter ones?
Yes, but it's important that your doctor knows about all other medicines you are taking, including those bought without a prescription, as well as herbal and complementary medicines. This is to ensure there are no interactions that could affect your health or the effectiveness of amlodipine. Also, be aware that some anti-inflammatory painkillers might reduce amlodipine's effectiveness.
What should I do if I forget to take a dose of amlodipine?
If you forget to take your dose at the usual time, take it as soon as you remember. However, if you don't remember until the following day, skip the missed dose and continue with your regular schedule. Do not take two doses together to make up for a forgotten dose.
Are there any specific drinks or foods I should avoid while taking amlodipine?
You should not drink large quantities of grapefruit juice while taking amlodipine. A chemical in grapefruit juice can increase the amount of amlodipine in your bloodstream, which could make side-effects more likely.
How long will I need to take amlodipine?
Treatment with amlodipine is usually long-term. You should continue taking the tablets unless your doctor tells you otherwise. If your doctor decides you need to stop, they may advise you to reduce your dose gradually over a few days, as suddenly stopping can cause your symptoms to return.
What should I do if I experience side-effects that don't go away?
When you first start amlodipine, you might experience headaches, flushing, or dizziness, which usually go away within a few days. If these, or any other side-effects, continue or become troublesome, you should let your doctor know. They can provide further advice or adjust your treatment if needed.
Lecturas adicionales y referencias
- Manufacturer's PIL, Amlodipine 5 mg and 10 mg Tablets; Mylan, The electronic Medicines Compendium. Dated July 2022.
- Medicamentos Completos BNF 89ª Edición; Asociación Médica Británica y Sociedad Real de Farmacia de Gran Bretaña, Londres.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Historial del artículo
La información en esta página está escrita y revisada por pares por clínicos calificados.
Próxima revisión: 3 Jul 2026
4 Jul 2023 | Última versión

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