Can I take Vortioxetine and Zopiclone together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can make you feel much more sleepy, drowsy, or dizzy than usual. It can also increase the risk of confusion, clumsiness, and falls, especially in older adults. You may find it harder to concentrate or perform tasks that require alertness.
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Why this happens
Both vortioxetine (an antidepressant) and zopiclone (a sleeping pill) affect the central nervous system. When used together, their sedative effects add up, leading to increased drowsiness and impaired coordination.
What you should do
Back to contentsUse this combination with caution. Do not drive, operate machinery, or perform dangerous tasks until you know how these medicines affect you together. Avoid drinking alcohol, as this will make the sleepiness much worse. If you feel excessively drowsy or confused, contact your doctor to see if your doses need adjusting.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking fluoxetine with Abilify (aripiprazole) can significantly increase the amount of Abilify in your bloodstream. This makes you much more likely to experience side effects such as extreme sleepiness, restlessness (feeling like you cannot sit still), uncontrollable body movements (tremors or twitching), and dizziness. There is also a small but serious risk of a heart rhythm problem called QT prolongation.

Treatment and medication
Can I take Folitrax and Hqtor together?
Taking Folitrax (methotrexate) and Hqtor (hydroxychloroquine) together can increase the risk of side effects, particularly those affecting the liver. However, these two medicines are very commonly prescribed together by specialists to treat conditions like rheumatoid arthritis. While they work well as a team to control inflammation, they require careful monitoring.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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